Hereditary angioedema (HAE), characterized by recurrent episodes of angioedema
involving the skin, or the mucosa of the upper respiratory or the gastrointestinal tracts, results …

The human blood coagulation system comprises a series of linked glycoproteins that upon
activation induce the generation of downstream enzymes ultimately forming fibrin. This …

The plasma zymogens factor XII (fXII) and factor XI (fXI) contribute to thrombosis in a variety
of mouse models. These proteins serve a limited role in hemostasis, suggesting that …

Recent studies indicate that the plasma contact system plays an important role in
thrombosis, despite being dispensable for hemostasis. For example, mice deficient in …

Abstract Background. Mycograb (Neu Tec Pharma) is a human recombinant monoclonal
antibody against heat shock protein 90 that, in laboratory studies, was revealed to have …

Effective hemorrhage control becomes increasingly significant in today's military and civilian
trauma, and current available local hemostatic agents have been reported to have various …

The plasma kallikrein-kinin system (KKS) plays a critical role in human physiology. The KKS
encompasses coagulation factor XII (FXII), the complex of prekallikrein (PK) and high …

Self-non-self discrimination has long been considered the main function of the immune
system. Increasing evidence supports the view of the immune system as a network of …

Heat-shock proteins (hsps) have been identified as molecular chaperones conserved
between microbes and man and grouped by their molecular mass and high degree of amino …

Hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS)
are diseases caused by hantavirus infections and are characterized by vascular leakage …