The pathophysiology of hereditary angioedema
AE Davis III - Clinical Immunology, 2005 - Elsevier
Hereditary angioedema (HAE), characterized by recurrent episodes of angioedema
involving the skin, or the mucosa of the upper respiratory or the gastrointestinal tracts, results …
involving the skin, or the mucosa of the upper respiratory or the gastrointestinal tracts, results …
The blood coagulation system as a molecular machine
HMH Spronk, JWP Govers‐Riemslag, H Ten Cate - Bioessays, 2003 - Wiley Online Library
The human blood coagulation system comprises a series of linked glycoproteins that upon
activation induce the generation of downstream enzymes ultimately forming fibrin. This …
activation induce the generation of downstream enzymes ultimately forming fibrin. This …
Factor XII inhibition reduces thrombus formation in a primate thrombosis model
A Matafonov, PY Leung, AE Gailani… - Blood, The Journal …, 2014 - ashpublications.org
The plasma zymogens factor XII (fXII) and factor XI (fXI) contribute to thrombosis in a variety
of mouse models. These proteins serve a limited role in hemostasis, suggesting that …
of mouse models. These proteins serve a limited role in hemostasis, suggesting that …
Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding
AS Revenko, D Gao, JR Crosby… - Blood, The Journal …, 2011 - ashpublications.org
Recent studies indicate that the plasma contact system plays an important role in
thrombosis, despite being dispensable for hemostasis. For example, mice deficient in …
thrombosis, despite being dispensable for hemostasis. For example, mice deficient in …
A randomized, blinded, multicenter trial of lipid-associated amphotericin B alone versus in combination with an antibody-based inhibitor of heat shock protein 90 in …
J Pachl, P Svoboda, F Jacobs… - Clinical Infectious …, 2006 - academic.oup.com
Abstract Background. Mycograb (Neu Tec Pharma) is a human recombinant monoclonal
antibody against heat shock protein 90 that, in laboratory studies, was revealed to have …
antibody against heat shock protein 90 that, in laboratory studies, was revealed to have …
Degradable, antibacterial silver exchanged mesoporous silica spheres for hemorrhage control
C Dai, Y Yuan, C Liu, J Wei, H Hong, X Li, X Pan - Biomaterials, 2009 - Elsevier
Effective hemorrhage control becomes increasingly significant in today's military and civilian
trauma, and current available local hemostatic agents have been reported to have various …
trauma, and current available local hemostatic agents have been reported to have various …
Human plasma kallikrein-kinin system: physiological and biochemical parameters
JW Bryant, Z Shariat-Madar - Cardiovascular & Hematological …, 2009 - ingentaconnect.com
The plasma kallikrein-kinin system (KKS) plays a critical role in human physiology. The KKS
encompasses coagulation factor XII (FXII), the complex of prekallikrein (PK) and high …
encompasses coagulation factor XII (FXII), the complex of prekallikrein (PK) and high …
The role of complement in danger sensing and transmission
J Köhl - Immunologic research, 2006 - Springer
Self-non-self discrimination has long been considered the main function of the immune
system. Increasing evidence supports the view of the immune system as a network of …
system. Increasing evidence supports the view of the immune system as a network of …
Fungal heat-shock proteins in human disease
JP Burnie, TL Carter, SJ Hodgetts… - FEMS microbiology …, 2006 - academic.oup.com
Heat-shock proteins (hsps) have been identified as molecular chaperones conserved
between microbes and man and grouped by their molecular mass and high degree of amino …
between microbes and man and grouped by their molecular mass and high degree of amino …
Endothelial cell permeability during hantavirus infection involves factor XII-dependent increased activation of the kallikrein-kinin system
SL Taylor, V Wahl-Jensen, AM Copeland… - PLoS …, 2013 - journals.plos.org
Hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS)
are diseases caused by hantavirus infections and are characterized by vascular leakage …
are diseases caused by hantavirus infections and are characterized by vascular leakage …