Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an
essential role in regulating many physiological processes, such as intracellular signaling …

Despite its enduring relevance as the single most effective and important evidence-based
treatment for schizophrenia, underutilization of clozapine remains considerable. To a …

Introduction In the framework of the IMI2-NeuroDeRisk consortium, three in vitro
electrophysiology assays were compared to improve preclinical prediction of seizure …

Treatment resistance in schizophrenia is often encountered in clinical practice, with
clozapine usually recommended as the appropriate therapy. However, where clozapine …

Background: Clozapine is more effective than other atypical antipsychotics for treatment
resistant schizophrenia, but has serious side effects. Clozapine has an estimated cumulative …

Abstract The Side Effects of Drugs Annuals is a series of volumes in which the adverse
effects of drugs and adverse reactions to them are surveyed. The series supplements the …

BACKGROUND Treatment-resistant schizophrenia is a severe form of schizophrenia
characterized by poor response to at least two antipsychotic drugs and is typically treated …

There are very few reports which suggest an association between antipsychotic clozapine
low dose and seizure. We report a case in which intial titration of low dose clozapine …

Schizophrenic patients resistant to antipsychotics are diagnosed as having treatment-
refractory schizophrenia, and they are treated with clozapine. However, clozapine is …

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