In the era of precision medicine, digital technologies and artificial intelligence, drug
discovery and development face unprecedented opportunities for product and business …

In the past decades, reductionism has dominated both research directions and funding
policies in clinical psychology and psychiatry. The intense search for the biological basis of …

The plasticity of the central nervous system helps form the basis for the neurobiology of
learning and memory. Long-term potentiation (LTP) is the main form of synaptic plasticity …

A statistical model is presented for computing probabilities that proteins are present in a
sample on the basis of peptides assigned to tandem mass (MS/MS) spectra acquired from a …

2002/0012939 A1 1/2002 Palsson et al. 2002/0051998 A1 5, 2002 Schmidt et al.
2002/0168654 A1 11/2002 Maranas et al. 2003/0059792 A1 3/2003 Palsson et al …

The systematic accumulation of gene expression data, although revolutionary, is insufficient
in itself for an understanding of system-level physiology. In the post-genomic era, the next …

It has been well-recognized that inflammation alongside tissue repair and damage
maintaining tissue homeostasis determines the initiation and progression of complex …

Clustering individuals to subpopulations based on genetic data has become commonplace
in many genetic studies. Inference about population structure is most often done by applying …

Unlike traditional biological research that focuses on a small set of components, systems
biology studies the complex interactions among a large number of genes, proteins, and …

This book delivers a comprehensive and insightful account of applying mathematical
modelling approaches to very large biological systems and networks—a fundamental aspect …