Translational precision medicine: an industry perspective
In the era of precision medicine, digital technologies and artificial intelligence, drug
discovery and development face unprecedented opportunities for product and business …
discovery and development face unprecedented opportunities for product and business …
Brain disorders? Not really: Why network structures block reductionism in psychopathology research
D Borsboom, AOJ Cramer, A Kalis - Behavioral and Brain Sciences, 2019 - cambridge.org
In the past decades, reductionism has dominated both research directions and funding
policies in clinical psychology and psychiatry. The intense search for the biological basis of …
policies in clinical psychology and psychiatry. The intense search for the biological basis of …
Glutamate receptors and signal transduction in learning and memory
S Peng, Y Zhang, J Zhang, H Wang, B Ren - Molecular biology reports, 2011 - Springer
The plasticity of the central nervous system helps form the basis for the neurobiology of
learning and memory. Long-term potentiation (LTP) is the main form of synaptic plasticity …
learning and memory. Long-term potentiation (LTP) is the main form of synaptic plasticity …
A statistical model for identifying proteins by tandem mass spectrometry
AI Nesvizhskii, A Keller, E Kolker… - Analytical …, 2003 - ACS Publications
A statistical model is presented for computing probabilities that proteins are present in a
sample on the basis of peptides assigned to tandem mass (MS/MS) spectra acquired from a …
sample on the basis of peptides assigned to tandem mass (MS/MS) spectra acquired from a …
Methods and systems to identify operational reaction pathways
2002/0012939 A1 1/2002 Palsson et al. 2002/0051998 A1 5, 2002 Schmidt et al.
2002/0168654 A1 11/2002 Maranas et al. 2003/0059792 A1 3/2003 Palsson et al …
2002/0168654 A1 11/2002 Maranas et al. 2003/0059792 A1 3/2003 Palsson et al …
Integrative gene-metabolite network with implemented causality deciphers informational fluxes of sulphur stress response
VJ Nikiforova, CO Daub, H Hesse… - Journal of …, 2005 - academic.oup.com
The systematic accumulation of gene expression data, although revolutionary, is insufficient
in itself for an understanding of system-level physiology. In the post-genomic era, the next …
in itself for an understanding of system-level physiology. In the post-genomic era, the next …
Molecular and genetic inflammation networks in major human diseases
It has been well-recognized that inflammation alongside tissue repair and damage
maintaining tissue homeostasis determines the initiation and progression of complex …
maintaining tissue homeostasis determines the initiation and progression of complex …
Inference and analysis of population structure using genetic data and network theory
Clustering individuals to subpopulations based on genetic data has become commonplace
in many genetic studies. Inference about population structure is most often done by applying …
in many genetic studies. Inference about population structure is most often done by applying …
Host–pathogen systems biology
CV Forst - Infectious disease informatics, 2010 - Springer
Unlike traditional biological research that focuses on a small set of components, systems
biology studies the complex interactions among a large number of genes, proteins, and …
biology studies the complex interactions among a large number of genes, proteins, and …
[图书][B] An introduction to computational systems biology: systems-level modelling of cellular networks
K Raman - 2021 - taylorfrancis.com
This book delivers a comprehensive and insightful account of applying mathematical
modelling approaches to very large biological systems and networks—a fundamental aspect …
modelling approaches to very large biological systems and networks—a fundamental aspect …