Bioprocessing and purification of extracellular L-asparaginase produced by endophytic Colletotrichum gloeosporioides and its anticancer activity
L-asparaginase is an enzyme commonly used to treat acute lymphoblastic leukemia.
Commercialized bacterial L-asparaginase has been reported to cause several life …
Commercialized bacterial L-asparaginase has been reported to cause several life …
Development of a bioengineered Erwinia chrysanthemi asparaginase to enhance its anti-solid tumor potential for treating gastric cancer
SY Tam, SF Chung, CF Kim, JC To, PK So… - International Journal of …, 2023 - Elsevier
Asparaginase has been traditionally applied for only treating acute lymphoblastic leukemia
due to its ability to deplete asparagine. However, its ultimate anticancer potential for treating …
due to its ability to deplete asparagine. However, its ultimate anticancer potential for treating …
L-asparaginase-mediated Therapy in L-asparagine Auxotrophic Cancers: A Review
R Sindhu, HK Manonmani - Anti-Cancer Agents in Medicinal …, 2022 - ingentaconnect.com
Microbial L-asparaginase is the most effective first-line therapy used in the treatment
protocols of paediatric and adult leukemia. Leukemic cells' auxotrophy for L-asparagine is …
protocols of paediatric and adult leukemia. Leukemic cells' auxotrophy for L-asparagine is …
Antarctic environments as a source of bacterial and fungal therapeutic enzymes
IGO Lima, JRS Bispo, AYH Agostinho… - Anais da Academia …, 2022 - SciELO Brasil
Microbial therapeutic enzymes are the protagonists in the pharmacological treatment of
different human diseases. The intrinsic enzymatic characteristics, such as high affinity and …
different human diseases. The intrinsic enzymatic characteristics, such as high affinity and …
Reduction-responsive immobilised and protected enzymes
We report a synthetic strategy to produce nano-immobilised and organosilica-shielded
enzymes of which the biocatalytic activity is, by design, chemically enhanced under …
enzymes of which the biocatalytic activity is, by design, chemically enhanced under …
Understanding the effect of measurement time on drug characterization
H Murphy, G McCarthy, HM Dobrovolny - Plos one, 2020 - journals.plos.org
In order to determine correct dosage of chemotherapy drugs, the effect of the drug must be
properly quantified. There are two important values that characterize the effect of the drug: ε …
properly quantified. There are two important values that characterize the effect of the drug: ε …
Antarctic environments as a source of bacterial and fungal therapeutic enzymes
GO Igor, AWF Duarte, JRS Bispo, AYH Agostinho… - …, 2022 - repositorio.ufmg.br
Microbial therapeutic enzymes are the protagonists in the pharmacological treatment of
different human diseases. The intrinsic enzymatic characteristics, such as high affinity and …
different human diseases. The intrinsic enzymatic characteristics, such as high affinity and …
Isolation and Anti-Leukemic Characterization of Extracellular L-asparaginase From Endophytic Bacterium, Brevibacterium sp. M-R21 Isolated Glycyrrhiza glabra Root
H Esmaeil Lashgarian, M Karkhane… - Article in Biointerface …, 2020 - eprints.lums.ac.ir
L-Asparaginase (L-ASPase) is known as a potent anti-cancer drug against L-
Asparagineauxotroph tumor cells. In this study, an endophytic L-ASPase producing …
Asparagineauxotroph tumor cells. In this study, an endophytic L-ASPase producing …