Gene therapies for cancer: strategies, challenges and successes
SK Das, ME Menezes, S Bhatia… - Journal of cellular …, 2015 - Wiley Online Library
Gene therapy, which involves replacement of a defective gene with a functional, healthy
copy of that gene, is a potentially beneficial cancer treatment approach particularly over …
copy of that gene, is a potentially beneficial cancer treatment approach particularly over …
Systemic delivery of oncolytic viruses: hopes and hurdles
MS Ferguson, NR Lemoine, Y Wang - Advances in virology, 2012 - Wiley Online Library
Despite recent advances in both surgery and chemoradiotherapy, mortality rates for
advanced cancer remain high. There is a pressing need for novel therapeutic strategies; one …
advanced cancer remain high. There is a pressing need for novel therapeutic strategies; one …
Gene therapy progress and prospects: ultrasound for gene transfer
CMH Newman, T Bettinger - Gene therapy, 2007 - nature.com
Ultrasound exposure (USE) in the presence of microbubbles (MCB)(eg contrast agents used
to enhance ultrasound imaging) increases plasmid transfection efficiency in vitro by several …
to enhance ultrasound imaging) increases plasmid transfection efficiency in vitro by several …
Drug loaded microbubble design for ultrasound triggered delivery
I Lentacker, SC De Smedt, NN Sanders - Soft Matter, 2009 - pubs.rsc.org
Ultrasound imaging is widely used in both diagnosis of diseases and pregnancy follow-up.
As ultrasound imaging is a harmless, cheap and portable technique, ultrasound guided drug …
As ultrasound imaging is a harmless, cheap and portable technique, ultrasound guided drug …
Microbubbles as ultrasound triggered drug carriers
Originally developed as contrast agents for ultrasound imaging and diagnostics, in the past
years, microbubbles have made their way back from the patients' bedside to the researcher's …
years, microbubbles have made their way back from the patients' bedside to the researcher's …
Ultrasound-enhanced drug delivery for cancer
S Mo, CC Coussios, L Seymour… - Expert opinion on drug …, 2012 - Taylor & Francis
Introduction: Ultrasound, which has traditionally been used as a diagnostic tool, is
increasingly being used in non-invasive therapy and drug delivery. Areas covered: Of …
increasingly being used in non-invasive therapy and drug delivery. Areas covered: Of …
Ultrasound targeted CNS gene delivery for Parkinson's disease treatment
Parkinson's disease (PD) is a potent neurodegenerative disease in which a progressive loss
of dopaminergic neurons eventually produces a loss of movement control and other …
of dopaminergic neurons eventually produces a loss of movement control and other …
Achieving systemic delivery of oncolytic viruses
C Hill, R Carlisle - Expert opinion on drug delivery, 2019 - Taylor & Francis
Introduction: Oncolytic virotherapy is a selective and powerful tool for cancer treatment.
Studies proving the ability of oncolytic viruses (OVs) to target and rapidly kill cancer cells …
Studies proving the ability of oncolytic viruses (OVs) to target and rapidly kill cancer cells …
mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity
Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a unique
member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with …
member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with …
Microbubbles as a vehicle for gene and drug delivery: current clinical implications and future perspectives
NA Geis, HA Katus… - Current pharmaceutical …, 2012 - ingentaconnect.com
Ultrasound targeted microbubble destruction (UTMD) has evolved as a novel system for non-
invasive, organ-and tissuespecific drug and gene delivery. Initially developed as ultrasound …
invasive, organ-and tissuespecific drug and gene delivery. Initially developed as ultrasound …