Gene therapies for cancer: strategies, challenges and successes

SK Das, ME Menezes, S Bhatia… - Journal of cellular …, 2015 - Wiley Online Library
Gene therapy, which involves replacement of a defective gene with a functional, healthy
copy of that gene, is a potentially beneficial cancer treatment approach particularly over …

Systemic delivery of oncolytic viruses: hopes and hurdles

MS Ferguson, NR Lemoine, Y Wang - Advances in virology, 2012 - Wiley Online Library
Despite recent advances in both surgery and chemoradiotherapy, mortality rates for
advanced cancer remain high. There is a pressing need for novel therapeutic strategies; one …

Gene therapy progress and prospects: ultrasound for gene transfer

CMH Newman, T Bettinger - Gene therapy, 2007 - nature.com
Ultrasound exposure (USE) in the presence of microbubbles (MCB)(eg contrast agents used
to enhance ultrasound imaging) increases plasmid transfection efficiency in vitro by several …

Drug loaded microbubble design for ultrasound triggered delivery

I Lentacker, SC De Smedt, NN Sanders - Soft Matter, 2009 - pubs.rsc.org
Ultrasound imaging is widely used in both diagnosis of diseases and pregnancy follow-up.
As ultrasound imaging is a harmless, cheap and portable technique, ultrasound guided drug …

Microbubbles as ultrasound triggered drug carriers

S Tinkov, R Bekeredjian, G Winter, C Coester - Journal of pharmaceutical …, 2009 - Elsevier
Originally developed as contrast agents for ultrasound imaging and diagnostics, in the past
years, microbubbles have made their way back from the patients' bedside to the researcher's …

Ultrasound-enhanced drug delivery for cancer

S Mo, CC Coussios, L Seymour… - Expert opinion on drug …, 2012 - Taylor & Francis
Introduction: Ultrasound, which has traditionally been used as a diagnostic tool, is
increasingly being used in non-invasive therapy and drug delivery. Areas covered: Of …

Ultrasound targeted CNS gene delivery for Parkinson's disease treatment

CH Fan, CY Lin, HL Liu, CK Yeh - Journal of Controlled Release, 2017 - Elsevier
Parkinson's disease (PD) is a potent neurodegenerative disease in which a progressive loss
of dopaminergic neurons eventually produces a loss of movement control and other …

Achieving systemic delivery of oncolytic viruses

C Hill, R Carlisle - Expert opinion on drug delivery, 2019 - Taylor & Francis
Introduction: Oncolytic virotherapy is a selective and powerful tool for cancer treatment.
Studies proving the ability of oncolytic viruses (OVs) to target and rapidly kill cancer cells …

mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity

R Dash, SK Bhutia, B Azab, Z Su, BA Quinn… - Cytokine & growth factor …, 2010 - Elsevier
Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a unique
member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with …

Microbubbles as a vehicle for gene and drug delivery: current clinical implications and future perspectives

NA Geis, HA Katus… - Current pharmaceutical …, 2012 - ingentaconnect.com
Ultrasound targeted microbubble destruction (UTMD) has evolved as a novel system for non-
invasive, organ-and tissuespecific drug and gene delivery. Initially developed as ultrasound …