Pharmacological cardioprotection against ischemia reperfusion injury—the search for a clinical effective therapy

Q Wang, CJ Zuurbier, R Huhn, C Torregroza… - Cells, 2023 - mdpi.com
Pharmacological conditioning aims to protect the heart from myocardial ischemia-
reperfusion injury (IRI). Despite extensive research in this area, today, a significant gap …

The Influence of Metabolic Risk Factors on the Inflammatory Response Triggered by Myocardial Infarction: Bridging Pathophysiology to Treatment

L Ramos-Regalado, S Alcover, L Badimon, G Vilahur - Cells, 2024 - mdpi.com
Myocardial infarction (MI) sets off a complex inflammatory cascade that is crucial for effective
cardiac healing and scar formation. Yet, if this response becomes excessive or uncontrolled …

Liposomal nanocarriers of preassembled glycocalyx expeditiously restore endothelial glycocalyx in endotoxemia

S Ishiko, G Ben Rahoma, S Kandhi… - American Journal of …, 2023 - journals.physiology.org
The endothelial glycocalyx (EG) is degraded early during sepsis, and currently available
treatments are not effective in promptly restoring it. Here, we created liposomal nanocarriers …

Dysregulated complement activation during acute myocardial infarction leads to endothelial glycocalyx degradation and endothelial dysfunction via the C5a: C5a …

C Vahldieck, S Löning, C Hamacher, B Fels… - Frontiers in …, 2024 - frontiersin.org
Introduction Complement-mediated damage to the myocardium during acute myocardial
infarction (AMI), particularly the late components of the terminal pathway (C5-convertase …

Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoE−/− mice

A Brückner, A Brandtner, S Rieck, M Matthey, C Geisen… - Angiogenesis, 2024 - Springer
Aortic aneurysm is characterized by a pathological dilation at specific predilection sites of
the vessel and potentially results in life-threatening vascular rupture. Herein, we established …

Permissive role of vascular endothelium in fibrosis: focus on the kidney

MS Goligorsky - American Journal of Physiology-Cell …, 2024 - journals.physiology.org
Fibrosis, the morphologic end-result of a plethora of chronic conditions and the scorch for
organ function, has been thoroughly investigated. One aspect of its development and …

Membrane potential dynamics of C5a-stimulated neutrophil granulocytes

S Becker, A Swoboda, H Siemer… - … -European Journal of …, 2024 - Springer
Neutrophil granulocytes play a crucial role in host defense against invading pathogens and
in inflammatory diseases. The aim of this study was to elucidate membrane potential …

Role of endothelial glycocalyx in central nervous system diseases and evaluation of the targeted therapeutic strategies for its protection: a review of clinical and …

W Ye, S Xu, Y Liu, Z Ye - Reviews in the Neurosciences, 2024 - degruyter.com
Central nervous system (CNS) diseases, such as stroke, traumatic brain injury, dementia,
and demyelinating diseases, are generally characterized by high morbidity and mortality …

The Impact of Maternal Passive Tobacco Smoke on Neonatal Myocardiopathy in Mice

N Kawish, MH Abbasi, MB Khawar… - Birth Defects …, 2024 - Wiley Online Library
Background Tobacco smoke has a global impact, particularly on pregnant women and their
newborns. An emerging body of research suggests that passive tobacco smoking is a …

Prolonged Door-to-Balloon Time Leads to Endothelial Glycocalyx Damage and Endothelial Dysfunction in Patients with ST-Elevation Myocardial Infarction

C Vahldieck, B Fels, S Löning, L Nickel, J Weil… - Biomedicines, 2023 - mdpi.com
Damage to the endothelial glycocalyx (eGC) has been reported during acute ischemic
events like ST-elevation myocardial infarction (STEMI). In STEMI, a door-to-balloon time …