Chemically engineered immune cell‐derived microrobots and biomimetic nanoparticles: emerging biodiagnostic and therapeutic tools

LP Jahromi, MA Shahbazi, A Maleki, A Azadi… - Advanced …, 2021 - Wiley Online Library
Over the past decades, considerable attention has been dedicated to the exploitation of
diverse immune cells as therapeutic and/or diagnostic cell‐based microrobots for hard‐to …

Nanotechnology in cell replacement therapies for type 1 diabetes

AU Ernst, DT Bowers, LH Wang, K Shariati… - Advanced drug delivery …, 2019 - Elsevier
Islet transplantation is a promising long-term, compliance-free, complication-preventing
treatment for type 1 diabetes. However, islet transplantation is currently limited to a narrow …

Polymeric micro-and nanoparticles for immune modulation

E Ben-Akiva, SE Witte, RA Meyer, KR Rhodes… - Biomaterials …, 2019 - pubs.rsc.org
New advances in biomaterial-based approaches to modulate the immune system are being
applied to treat cancer, infectious diseases, and autoimmunity. Particulate systems are …

Tolerogenic dendritic cells in organ transplantation

J Ochando, F Ordikhani, S Jordan, P Boros… - Transplant …, 2020 - Wiley Online Library
Dendritic cells (DC s) are specialized cells of the innate immune system that are
characterized by their ability to take up, process and present antigens (Ag) to effector T cells …

Tolerogenic Nano-/Microparticle Vaccines for Immunotherapy

Q Liu, G Chen, X Liu, L Tao, Y Fan, T Xia - ACS nano, 2024 - ACS Publications
Autoimmune diseases, allergies, transplant rejections, generation of antidrug antibodies,
and chronic inflammatory diseases have impacted a large group of people across the globe …

[HTML][HTML] Implantable immunosuppressant delivery to prevent rejection in transplantation

MR Anggelia, RW Huang, HY Cheng, CH Lin… - International Journal of …, 2022 - mdpi.com
An innovative immunosuppressant with a minimally invasive delivery system has emerged
in the biomedical field. The application of biodegradable and biocompatible polymer forms …

On-target and direct modulation of alloreactive T cells by a nanoparticle carrying MHC alloantigen, regulatory molecules and CD47 in a murine model of alloskin …

KA Shahzad, X Wan, L Zhang, W Pei, A Zhang… - Drug …, 2018 - Taylor & Francis
Biomimetic nanoparticles have been reported as immune modulators in autoimmune
diseases and allograft rejections by numerous researchers. However, most of the …

Design and optimization of PLGA particles to deliver immunomodulatory drugs for the prevention of skin allograft rejection

KA Shahzad, M Naeem, L Zhang, X Wan… - Immunological …, 2020 - Taylor & Francis
Background: Recent advancements in therapeutic strategies have attracted considerable
attention to control the acute organs and tissues rejection, which is the main cause of …

[HTML][HTML] Immunomodulatory effect of PLGA-encapsulated mesenchymal stem cells-derived exosomes for the treatment of allergic rhinitis

KA Shahzad, Z Wang, X Li, J Li, M Xu… - Frontiers in …, 2024 - frontiersin.org
Introduction Allergic rhinitis (AR) is an upper airway inflammatory disease of the nasal
mucosa. Conventional treatments such as symptomatic pharmacotherapy and allergen …

Biomimetic nanosponges for treating antibody-mediated autoimmune diseases

Y Jiang, RH Fang, L Zhang - Bioconjugate chemistry, 2018 - ACS Publications
Autoimmune diseases are characterized by overactive immunity, where the body's defense
system launches an attack against itself. If left unchecked, this can result in the destruction of …