Eph receptors and their ephrin ligands are viewed as promising targets for cancer treatment;
however, targeting them is hindered by their context-dependent functionalities. To …

Protein–protein interactions (PPIs) between modular binding domains and their target
peptide motifs are thought to largely depend on the intrinsic binding specificities of the …

EPH receptors (EPHRs) constitute the largest family among receptor tyrosine kinases in
humans. They are mainly involved in short-range cell-cell communication events that …

Purpose: Accumulating analyses of pro-oncogenic molecular mechanisms triggered a rapid
development of targeted cancer therapies. Although many of these treatments produce …

Targeting protein-protein interactions (PPIs) is a promising approach in the development of
drugs for many indications. 14-3-3 proteins are a family of phosphoprotein-binding …

Phosphotyrosine (pTyr) signaling has evolved into a key cell-to-cell communication system.
Activated receptor tyrosine kinases (RTKs) initiate several pTyr-dependent signaling …

Signals from cell surface receptors are often relayed via adaptor proteins. NCK1 and NCK2
are Src-Homology (SH) 2 and 3 domain adaptors that regulate processes requiring a …

Prostate cancer (PCa) is the most frequently diagnosed cancer in men and the third cause of
cancer mortality. PCa initiation and growth are driven by the androgen receptor (AR). The …

Background Maintenance of the kidney filtration barrier requires coordinated interactions
between podocytes and the underlying glomerular basement membrane (GBM). GBM …

HER2/ErbB2 is overexpressed in a significant fraction of breast tumours and is associated
with a poor prognosis. The adaptor protein GRB2 interacts directly with activated HER2 and …