Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Muscle atrophy is a common complication in chronic kidney disease (CKD). Inflammation
and myostatin play important roles in CKD muscle atrophy. Formononetin (FMN), which is a …

Aims Transforming growth factor‐β (TGF‐β) signalling is thought to contribute to the
remodelling of extracellular matrix (ECM) of skeletal muscle and to functional decline in …

Congenital myasthenic syndromes (CMS) result from reduced cholinergic transmission at
neuromuscular junctions (NMJs). While the etiology of CMS varies, the disease is …

Objectives: The aim of the study was to investigate if myostatin dysfunction can ameliorate
fasting-induced muscle wasting. Methods: 18-week old males from Berlin high (BEH) strain …

Myostatin is an inhibitor of skeletal muscle growth and might be involved in adaptations to
caloric restriction (CR). We compared responses to 12-week 30% CR in male mice of Berlin …

Genetic background contributes substantially to individual variability in muscle mass. Muscle
hypertrophy in response to resistance training can also vary extensively. However, it is less …

Fasting improves metabolic health, but is also associated with loss of lean body mass. We
investigated if old mice are less resistant to fasting-induce muscle wasting than adult mice …

Abstract [eng] Research Problem: Obesity causes deterioration in health and function of
many tissues through multiple metabolic changes. However, force generation of locomotory …

Introdução: A análise dos diversos fatores genéticos, principalmente os relacionados aos
polimorfismos de DNA, têm sido investigados na busca de uma melhor compreensão dos …