Genome-wide association studies
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …
across many genomes to find those statistically associated with a specific trait or disease …
Co‐morbidity between mood and anxiety disorders: A systematic review and meta‐analysis
There is consistent evidence that mood disorders often co‐occur with anxiety disorders,
however, the strength of the association of these two broad groups of disorders has been …
however, the strength of the association of these two broad groups of disorders has been …
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders
Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying
susceptibility genes could highlight the underlying pathophysiological mechanisms. We …
susceptibility genes could highlight the underlying pathophysiological mechanisms. We …
Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis
We interrogate the joint genetic architecture of 11 major psychiatric disorders at
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …
Exploring the genetic overlap between twelve psychiatric disorders
The widespread comorbidity among psychiatric disorders demonstrated in epidemiological
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …
Anxiety disorders in children and adolescents: A summary and overview of the literature
Considerable work has advanced understanding of the nature, causes, management, and
prevention of anxiety disorders in children and adolescents over the past 30 years. Prior to …
prevention of anxiety disorders in children and adolescents over the past 30 years. Prior to …
Genetic variants associated with anxiety and stress-related disorders: a genome-wide association study and mouse-model study
Importance Anxiety and stress-related disorders are among the most common mental
disorders. Although family and twin studies indicate that both genetic and environmental …
disorders. Although family and twin studies indicate that both genetic and environmental …
A genetically informed Registered Report on adverse childhood experiences and mental health
Children who experience adversities have an elevated risk of mental health problems.
However, the extent to which adverse childhood experiences (ACEs) cause mental health …
However, the extent to which adverse childhood experiences (ACEs) cause mental health …
Symptom-level modelling unravels the shared genetic architecture of anxiety and depression
Depression and anxiety are highly prevalent and comorbid psychiatric traits that cause
considerable burden worldwide. Here we use factor analysis and genomic structural …
considerable burden worldwide. Here we use factor analysis and genomic structural …