Flavonoids are a major group of phytoestrogens associated with physiological effects, and
ecological and social impacts. Although the estrogenic activity of flavonoids was reported by …

Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder that is difficult
to cure and characterized by periods of relapse. To face the challenges of limited treatment …

The blood–brain barrier (BBB) is a protective barrier for brain safety, but it is also a major
obstacle to the delivery of drugs to the cerebral parenchyma such as the hippocampus …

Icariin (ICA), one of the main active components of Herba Epimedii, is a natural prenylated
flavonol glycoside that possesses a wide range of pharmacological effects, including …

Periprosthetic osteolysis is one of the major long-term complications following total joint
replacement. Its cause is widely accepted to be wear particle-induced activation of …

Resveratrol is regarded as neutraceuticals with multiple health benefits. The introduction of
prenyl can enhance the bioactivity. In this work, the cancer preventive activities and …

Presently, guided bone regeneration (GBR) stands as a preeminent strategy for rectifying
periodontal and maxillofacial bone imperfections. Nonetheless, the current GBR membranes …

Herba epimedii (HEP), a kidney-tonifying herb, has been commonly used alone or in
formula for strengthening kidney function and treating bone disorders. Its bone protective …

Women go through several predictable conditions and symptoms during menopause that
are caused by age, changes in sex hormone levels, and other factors. Conventional …

Icariin, a flavonoid glycoside derived from Epimedium brevicornum Maxim, exerts bone
protective effects via estrogen receptors (ERs). This study aimed to investigate the role of ER …