Neuroinflammation is a multifaceted physiological and pathophysiological response of the
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …

Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …

Danger sensing is one of the most fundamental evolutionary features enabling multicellular
organisms to perceive potential threats, escape from risky situations, fight actual intruders …

Neuroinflammation is a key pathologic hallmark of numerous neurologic diseases, however,
its exact role in vivo is yet to be fully understood. PET imaging enables investigation …

Microglia, brain resident immune cells, modulate development, activity, and plasticity of the
central nervous system. Mechanistically implicated in numerous neurological pathologies …

Neuroinflammation is an adaptive response of the central nervous system to diverse
potentially injurious stimuli, which is closely associated with neurodegeneration and …

Colony-stimulating factor 1 receptor (CSF1R) is a specific biomarker for microglia. In this
study, we developed a novel PET radioligand for CSF1R, 11C-GW2580, and compared it to …

Purinergic receptors play important roles in central nervous system (CNS). These receptors
are involved in cellular neuroinflammatory responses that regulate functions of neurons …

P2X7 receptors are ion-gated channels activated by ATP. Under pathological conditions, the
extensive release of ATP induces sustained P2X7 receptor activation, culminating in …

Chronic active lesions are promotors of neurodegeneration and disease progression in
multiple sclerosis. They harbour a dense rim of activated innate immune cells at the lesion …