The utility of ctDNA in lung cancer clinical research and practice: a systematic review and meta-analysis of clinical studies

X Sun, P Abrahamson, N Ballew, L Kalilani… - Cancer …, 2023 - Taylor & Francis
This systematic review with embedded meta-analysis aimed to evaluate the clinical utility of
circulating tumor DNA (ctDNA) in lung cancer. After screening and review of the Embase …

Non-invasive lung cancer diagnosis and prognosis based on multi-analyte liquid biopsy

K Chen, J Sun, H Zhao, R Jiang, J Zheng, Z Li, J Peng… - Molecular cancer, 2021 - Springer
Lung cancer (LC) is the leading cause of death in many countries including China. The
stage at which LC is diagnosed has a significant impact on prognosis. However, timely …

Radiogenomic analysis of locally advanced lung cancer based on CT imaging and intratreatment changes in cell-free DNA

KJ Lafata, MN Corradetti, J Gao, CD Jacobs… - Radiology: Imaging …, 2021 - pubs.rsna.org
The radiologic appearance of locally advanced lung cancer may be linked to molecular
changes of the disease during treatment, but characteristics of this phenomenon are poorly …

Intrinsic radiomic expression patterns after 20 Gy demonstrate early metabolic response of oropharyngeal cancers

KJ Lafata, Y Chang, C Wang, YM Mowery… - Medical …, 2021 - Wiley Online Library
Purpose This study investigated the prognostic potential of intra‐treatment PET radiomics
data in patients undergoing definitive (chemo) radiation therapy for oropharyngeal cancer …

Longitudinal circulating tumor DNA profiling in metastatic colorectal cancer during anti-EGFR therapy

W Yang, J Zou, Y Li, R Liu, Z Yan, S Chen… - Frontiers in …, 2022 - frontiersin.org
Background Metastatic colorectal cancer (mCRC) is a heterogenous disease with limited
precision medicine and targeted therapy options. Monoclonal antibodies against epidermal …

Photon counting CT and radiomic analysis enables differentiation of tumors based on lymphocyte burden

AJ Allphin, YM Mowery, KJ Lafata, DP Clark, AM Bassil… - Tomography, 2022 - mdpi.com
The purpose of this study was to investigate if radiomic analysis based on spectral micro-CT
with nanoparticle contrast-enhancement can differentiate tumors based on lymphocyte …

Detectability of plasma-derived circulating tumor DNA panel in patients undergoing primary treatment for uveal melanoma

JH Francis, CA Barker, AR Brannon… - … & Visual Science, 2022 - iovs.arvojournals.org
Purpose: To investigate the presence of plasma circulating tumor DNA (ctDNA) in patients
with uveal melanoma during and after primary tumor treatment. Methods: Detectability and …

Artificial intelligence across oncology specialties: current applications and emerging tools

J Kang, K Lafata, E Kim, C Yao, F Lin, T Rattay… - BMJ …, 2024 - bmjoncology.bmj.com
Oncology is becoming increasingly personalised through advancements in precision in
diagnostics and therapeutics, with more and more data available on both ends to create …

Prognostic value of absolute quantification of mutated KRAS in circulating tumour DNA in lung adenocarcinoma patients prior to therapy

SGF Wahl, HY Dai, EF Emdal… - The Journal of …, 2021 - Wiley Online Library
Droplet digital polymerase chain reaction (ddPCR) is a highly sensitive and accurate
method for quantification of nucleic acid sequences. We used absolute quantification of …

Concordance-based Predictive Uncertainty (CPU)-Index: Proof-of-concept with application towards improved specificity of lung cancers on low dose screening CT

Y Wang, A Gupta, FI Tushar, B Riley, A Wang… - Artificial Intelligence in …, 2024 - Elsevier
In this paper, we introduce a novel concordance-based predictive uncertainty (CPU)-Index,
which integrates insights from subgroup analysis and personalized AI time-to-event models …