The NLRP3 inflammasome: activation and regulation
The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) inflammasome is a
cytoplasmic supramolecular complex that is activated in response to cellular perturbations …
cytoplasmic supramolecular complex that is activated in response to cellular perturbations …
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
KV Swanson, M Deng, JPY Ting - Nature Reviews Immunology, 2019 - nature.com
Abstract NLRP3 (NOD-, LRR-and pyrin domain-containing protein 3) is an intracellular
sensor that detects a broad range of microbial motifs, endogenous danger signals and …
sensor that detects a broad range of microbial motifs, endogenous danger signals and …
TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation
RA Irizarry-Caro, MM McDaniel… - Proceedings of the …, 2020 - National Acad Sciences
Macrophages respond to microbial ligands and various noxious cues by initiating an
inflammatory response aimed at eliminating the original pathogenic insult. Transition of …
inflammatory response aimed at eliminating the original pathogenic insult. Transition of …
A guide to immunometabolism for immunologists
LAJ O'Neill, RJ Kishton, J Rathmell - Nature reviews immunology, 2016 - nature.com
In recent years a substantial number of findings have been made in the area of
immunometabolism, by which we mean the changes in intracellular metabolic pathways in …
immunometabolism, by which we mean the changes in intracellular metabolic pathways in …
Mitochondria are the powerhouses of immunity
Recent evidence indicates that mitochondria lie at the heart of immunity. Mitochondrial DNA
acts as a danger-associated molecular pattern (DAMP), and the mitochondrial outer …
acts as a danger-associated molecular pattern (DAMP), and the mitochondrial outer …
New insights on the role of lipid metabolism in the metabolic reprogramming of macrophages
Macrophage activation is intimately linked to metabolic reprogramming. Inflammatory (M1)
macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by …
macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by …
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis
Plasma membrane perforation elicited by caspase cleavage of the gasdermin D (GSDMD) N-
terminal domain (GSDMD-NT) triggers pyroptosis. The mechanisms underlying GSDMD …
terminal domain (GSDMD-NT) triggers pyroptosis. The mechanisms underlying GSDMD …
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles
RQ Yao, C Ren, ZF Xia, YM Yao - Autophagy, 2021 - Taylor & Francis
The structural integrity and functional stability of organelles are prerequisites for the viability
and responsiveness of cells. Dysfunction of multiple organelles is critically involved in the …
and responsiveness of cells. Dysfunction of multiple organelles is critically involved in the …
The roles of macrophage polarization in the host immune response to sepsis
X Chen, Y Liu, Y Gao, S Shou, Y Chai - International immunopharmacology, 2021 - Elsevier
Sepsis is a life-threatening clinical syndrome caused by infection. Its pathogenesis is
complex and entails coagulation dysfunction, inflammation, and immune disorders …
complex and entails coagulation dysfunction, inflammation, and immune disorders …
[HTML][HTML] Tumour necrosis factor signalling in health and disease
J Holbrook, S Lara-Reyna, H Jarosz-Griffiths… - …, 2019 - ncbi.nlm.nih.gov
The master pro-inflammatory cytokine, tumour necrosis factor (TNF), has been shown to
modulate multiple signalling pathways, with wide-ranging downstream effects. TNF plays a …
modulate multiple signalling pathways, with wide-ranging downstream effects. TNF plays a …