Long recognized as an evolutionarily ancient cell type involved in tissue homeostasis and
immune defense against pathogens, macrophages are being re-discovered as regulators of …

Genomic stability in normal cells is crucial to avoid oncogenesis. Accordingly, multiple
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …

Infiltration of regulatory T (Treg) cells, an immunosuppressive population of CD4+ T cells,
into solid cancers represents a barrier to cancer immunotherapy. Chemokine receptors are …

Immune checkpoint blockade therapy with anti-PD-1 monoclonal antibody (mAb) is a
treatment for colorectal cancer (CRC). However, some patients remain unresponsive to PD …

Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify
combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4) …

Diffuse intrinsic pontine glioma (DIPG) is an aggressive brain stem tumor and the leading
cause of pediatric cancer-related death. To date, these tumors remain incurable …

Defective DNA mismatch repair (dMMR) is associated with many cancer types including
colon, gastric, endometrial, ovarian, hepatobiliary tract, urinary tract, brain and skin cancers …

Aging is associated with an increased incidence of autoimmune diseases, despite the
progressive decline of immune responses (immunosenescence). This apparent paradox can …

Colorectal cancer (CRC) is one of the most frequent tumor entities worldwide with only
limited therapeutic options. CRC is not only a genetic disease with several mutations in …

Up to 30% of colorectal, endometrial and gastric cancers have a deficiency in mismatch
repair (MMR) protein expression due to either germline or epigenetic inactivation. Patients …