We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

No other tissue in the body depends more on the composition and organization of the
extracellular matrix (ECM) for normal structure and function than the corneal stroma. The …

The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally
into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and …

The cornea consists primarily of three layers: an outer layer containing an epithelium, a
middle stromal layer consisting of a collagen-rich extracellular matrix (ECM) interspersed …

Small leucine‐rich proteoglycans (SLRP s) are involved in a variety of biological and
pathological processes. This review focuses on their regulatory roles in matrix assembly …

The small leucine-rich proteoglycan (SLRP) family has significantly expanded in the past
decade to now encompass five discrete classes, grouped by common structural and …

Although human epidemiological and genetic studies are essential to elucidate the
aetiology of normal and aberrant ocular development, animal models have provided us with …

Small leucine-rich proteoglycans (SLRPs) are extracellular molecules that bind to TGFβs
and collagens and other matrix molecules. In vitro, SLRPs were shown to regulate collagen …

Proteoglycans (PGs), molecules in which glycosaminoglycans (GAGs) are covalently linked
to a protein core, are components of the extracellular matrix of all multicellular organisms …

The transparent cornea is the major refractive element of the eye. A finely controlled
assembly of the stromal extracellular matrix is critical to corneal function, as well as in …