Auxetic metamaterials and structures are characterized by their negative Poisson's ratio
meaning that they exhibit lateral expansion under tensile axial loads and densification under …

Long-term nonunion of bone defects has always been a major problem in orthopedic
treatment. Artificial bone graft materials such as Poly (lactic-co-glycolic acid)/β-tricalcium …

Simple Summary This review explores various studies to understand how 3D cell cultures
mimic real tumour conditions and respond to anticancer drugs. This study focuses on …

Reproducing in vitro a model of the bone microenvironment is a current need. Preclinical in
vitro screening, drug discovery, as well as pathophysiology studies may benefit from in vitro …

The management of osteosarcoma (OS) patients presents a significant clinical challenge.
Despite progress in conventional and targeted therapies, the survival rate of OS patients …

Simple Summary For years, cancer has remained the second leading cause of death in US
and Europe even though cancer mortality has decreased, as new advances in medical …

Loading anti-cancer drugs into 3D polymeric platforms is a promising strategy for achieving
sustained release to solid cancer tissues while simultaneously prolonging device retention …

Bone metastasis primarily occurs when breast, prostate, or lung cancers disseminate
tumoral cells into bone tissue, leading to a range of complications in skeletal tissues and, in …

Primary bone tumors such as Ewing sarcoma, osteosarcoma, and chondrosarcoma,
secondary bone tumors developed from progressive malignancies, and metastasized bone …

Osteosarcoma (OS) is the most diagnosed bone tumor in children, and current in vitro
methods (2D cell culture and tumor spheroids) cannot appropriately reflect the real …