Exploring phytochemicals for combating antibiotic resistance in microbial pathogens

T Khare, U Anand, A Dey, YG Assaraf… - Frontiers in …, 2021 - frontiersin.org
Antibiotic resistance or microbial drug resistance is emerging as a serious threat to human
healthcare globally, and the multidrug-resistant (MDR) strains are imposing major hurdles to …

Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Bacterial multidrug efflux pumps at the frontline of antimicrobial resistance: an overview

L Huang, C Wu, H Gao, C Xu, M Dai, L Huang, H Hao… - Antibiotics, 2022 - mdpi.com
Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by
decreasing the intracellular concentration of drugs. This protective barrier consists of a …

Modification of silica nanoparticles for antibacterial activities: mechanism of action

M Alavi, S Thomas, M Sreedharan - Micro Nano Bio Aspects, 2022 - mnba-journal.com
Opening up a new avenue for smart design of nanomaterials by antibacterial agents such as
antibiotics, metal/metal oxide nanoparticles (NPs), and polymeric materials to achieve high …

Honey: another alternative in the fight against antibiotic-resistant bacteria?

P Combarros-Fuertes, JM Fresno, MM Estevinho… - Antibiotics, 2020 - mdpi.com
Antibacterial resistance has become a challenging situation worldwide. The increasing
emergence of multidrug-resistant pathogens stresses the need for developing alternative or …

Antimicrobial activity and mechanism of limonene against Staphylococcus aureus

Y Han, W Chen, Z Sun - Journal of Food Safety, 2021 - Wiley Online Library
In this study, inhibitory effect of limonene on Staphylococcus aureus (S. aureus) and its
antibacterial mechanism was explored, respectively. The results showed that limonene …

Antibiotic potentiators against multidrug-resistant bacteria: discovery, development, and clinical relevance

M Chawla, J Verma, R Gupta, B Das - Frontiers in Microbiology, 2022 - frontiersin.org
Antimicrobial resistance in clinically important microbes has emerged as an unmet
challenge in global health. Extensively drug-resistant bacterial pathogens have cropped up …

Efflux pump mediated antimicrobial resistance by staphylococci in health-related environments: challenges and the quest for inhibition

A Dashtbani-Roozbehani, MH Brown - Antibiotics, 2021 - mdpi.com
The increasing emergence of antimicrobial resistance in staphylococcal bacteria is a major
health threat worldwide due to significant morbidity and mortality resulting from their …

Terpenes as bacterial efflux pump inhibitors: A systematic review

KJSDO Dias, GM Miranda, JR Bessa… - Frontiers in …, 2022 - frontiersin.org
Managing antibiotic resistance is a significant challenge in modern pharmacotherapy. While
molecular analyses have identified efflux pump expression as an essential mechanism …

Mannosylated Systems for Targeted Delivery of Antibacterial Drugs to Activated Macrophages

ID Zlotnikov, MA Vigovskiy, MP Davydova… - International Journal of …, 2022 - mdpi.com
Macrophages are a promising target for drug delivery to influence macrophage-associated
processes in the body, namely due to the presence of resistant microorganisms in …