The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Chronic pain affects the life quality of the suffering patients and posts heavy problems to the
health care system. Conventional medications are usually insufficient for chronic pain …

Background and Purpose Gout arthritis, which is provoked by monosodium urate (MSU)
crystal accumulation in the joint and periarticular tissues, induces severe pain and affects …

TRPA1 is a non‐selective cation channel expressed in mammalian peripheral pain
receptors, with a major role in chemonociception. TRPA1 has also been implicated in …

The transient receptor potential ankyrin 1 (TRPA1) channel is a nonselective cation channel
belonging to the superfamily of transient receptor potential (TRP) channels. It is …

According to the International Association for the Study of Pain (IASP) pain is characterized
as an “unpleasant sensory and emotional experience associated with actual or potential …

A complex network of many interacting mechanisms orchestrates immune and inflammatory
responses. Among these, the cation channels of the transient receptor potential (TRP) family …

Crystal structures activate innate immune cells, especially macrophages and initiate
inflammatory responses. We aimed to understand the role of the mechanosensitive TRPV4 …

Glyceryl trinitrate is administered as a provocative test for migraine pain. Glyceryl trinitrate
causes prolonged mechanical allodynia in rodents, which temporally correlates with …

Transient receptor potential (TRP) are cation channels expressed in both non-excitable and
excitable cells from diverse tissues, including heart, lung, and brain. The TRP channel family …