Stimulated emission depletion microscopy

H Blom, J Widengren - Chemical reviews, 2017 - ACS Publications
Despite its short history, diffraction-unlimited fluorescence microscopy techniques have
already made a substantial imprint in the biological sciences. In this review, we describe …

Cardiac T-tubule microanatomy and function

TT Hong, RM Shaw - Physiological reviews, 2017 - journals.physiology.org
Unique to striated muscle cells, transverse tubules (t-tubules) are membrane organelles that
consist of sarcolemma penetrating into the myocyte interior, forming a highly branched and …

Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm

M Cerrone, J Montnach, X Lin, YT Zhao… - Nature …, 2017 - nature.com
Abstract Plakophilin-2 (PKP2) is a component of the desmosome and known for its role in
cell–cell adhesion. Mutations in human PKP2 associate with a life-threatening …

Cardiac mechano-gated ion channels and arrhythmias

R Peyronnet, JM Nerbonne, P Kohl - Circulation research, 2016 - Am Heart Assoc
Mechanical forces will have been omnipresent since the origin of life, and living organisms
have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The …

Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia

TT Hong, H Yang, SS Zhang, HC Cho… - Nature medicine, 2014 - nature.com
Cardiomyocyte T tubules are important for regulating ion flux. Bridging integrator 1 (BIN1) is
a T-tubule protein associated with calcium channel trafficking that is downregulated in failing …

The physiology and pathophysiology of T-tubules in the heart

IE Setterberg, C Le, M Frisk, H Perdreau-Dahl… - Frontiers in …, 2021 - frontiersin.org
In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

The role of junctophilin proteins in cellular function

SE Lehnart, XHT Wehrens - Physiological reviews, 2022 - journals.physiology.org
Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …

Cellular mechanosensing: getting to the nucleus of it all

GR Fedorchak, A Kaminski, J Lammerding - Progress in biophysics and …, 2014 - Elsevier
Cells respond to mechanical forces by activating specific genes and signaling pathways that
allow the cells to adapt to their physical environment. Examples include muscle growth in …

[HTML][HTML] Cardiac disorders and pathophysiology of sarcomeric proteins

J van der Velden, GJM Stienen - Physiological reviews, 2018 - journals.physiology.org
The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

Emerging mechanisms of T-tubule remodelling in heart failure

A Guo, C Zhang, S Wei, B Chen… - Cardiovascular …, 2013 - academic.oup.com
Cardiac excitation–contraction coupling occurs primarily at the sites of transverse (T)-
tubule/sarcoplasmic reticulum junctions. The orderly T-tubule network guarantees the …