DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer
RX Huang, PK Zhou - Signal transduction and targeted therapy, 2020 - nature.com
Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …
tumors. However, the radioresistance of cancer cells is still a major limitation for …
The MRE11–RAD50–NBS1 complex conducts the orchestration of damage signaling and outcomes to stress in DNA replication and repair
Genomic instability in disease and its fidelity in health depend on the DNA damage
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi
VM Gantz, N Jasinskiene… - Proceedings of the …, 2015 - National Acad Sciences
Genetic engineering technologies can be used both to create transgenic mosquitoes
carrying antipathogen effector genes targeting human malaria parasites and to generate …
carrying antipathogen effector genes targeting human malaria parasites and to generate …
DNA damage and associated DNA repair defects in disease and premature aging
Genetic information is constantly being attacked by intrinsic and extrinsic damaging agents,
such as reactive oxygen species, atmospheric radiation, environmental chemicals, and …
such as reactive oxygen species, atmospheric radiation, environmental chemicals, and …
Error‐prone repair of DNA double‐strand breaks
K Rodgers, M McVey - Journal of cellular physiology, 2016 - Wiley Online Library
Preserving the integrity of the DNA double helix is crucial for the maintenance of genomic
stability. Therefore, DNA double‐strand breaks represent a serious threat to cells. In this …
stability. Therefore, DNA double‐strand breaks represent a serious threat to cells. In this …
Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth
regulator that responds to multiple environmental cues. Amino acids stimulate, in a Rag …
regulator that responds to multiple environmental cues. Amino acids stimulate, in a Rag …
Mechanisms of ATM activation
TT Paull - Annual review of biochemistry, 2015 - annualreviews.org
The ataxia-telangiectasia mutated (ATM) protein kinase is a master regulator of the DNA
damage response, and it coordinates checkpoint activation, DNA repair, and metabolic …
damage response, and it coordinates checkpoint activation, DNA repair, and metabolic …
[HTML][HTML] Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer
G Borrego-Soto, R Ortiz-López… - Genetics and molecular …, 2015 - SciELO Brasil
Breast cancer is the most common malignancy in women. Radiotherapy is frequently used in
patients with breast cancer, but some patients may be more susceptible to ionizing radiation …
patients with breast cancer, but some patients may be more susceptible to ionizing radiation …
PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair
XRCC4 and XLF are two structurally related proteins that function in DNA double-strand
break (DSB) repair. Here, we identify human PAXX (PAralog of XRCC4 and XLF, also called …
break (DSB) repair. Here, we identify human PAXX (PAralog of XRCC4 and XLF, also called …
DNA double-strand break resection occurs during non-homologous end joining in G1 but is distinct from resection during homologous recombination
R Biehs, M Steinlage, O Barton, S Juhász, J Künzel… - Molecular cell, 2017 - cell.com
Canonical non-homologous end joining (c-NHEJ) repairs DNA double-strand breaks (DSBs)
in G1 cells with biphasic kinetics. We show that DSBs repaired with slow kinetics, including …
in G1 cells with biphasic kinetics. We show that DSBs repaired with slow kinetics, including …