Animal models of chemotherapy-induced cognitive decline in preclinical drug development

J John, M Kinra, J Mudgal, GL Viswanatha… - …, 2021 - Springer
Rationale Chemotherapy-induced cognitive impairment (CICI), chemobrain, and chemofog
are the common terms for mental dysfunction in a cancer patient/survivor under the influence …

Pathogenesis, assessments, and management of chemotherapy‐related cognitive impairment (CRCI): an updated literature review

L Lv, S Mao, H Dong, P Hu, R Dong - Journal of oncology, 2020 - Wiley Online Library
There are various cancer treatments at present, and chemotherapy is one of the main
methods. Chemotherapy‐related cognitive impairment (CRCI), as one of the side effects of …

Role of inflammation and oxidative stress in chemotherapy-induced neurotoxicity

P Gupta, TK Makkar, L Goel, M Pahuja - Immunologic Research, 2022 - Springer
Chemotherapeutic agents may adversely affect the nervous system, including the neural
precursor cells as well as the white matter. Although the mechanisms are not completely …

CAR t-cell therapy in BOlogNa–NEUrotoxicity TReatment and Assessment in Lymphoma (CARBON–NEUTRAL): proposed protocol and results from an Italian study

U Pensato, G Amore, L Muccioli, S Sammali… - Journal of …, 2023 - Springer
Objective To investigate neurotoxicity clinical and instrumental features, incidence, risk
factors, and early and long-term prognosis in lymphoma patients who received CAR T-cell …

[HTML][HTML] HDAC6 inhibition reverses long-term doxorubicin-induced cognitive dysfunction by restoring microglia homeostasis and synaptic integrity

BR McAlpin, R Mahalingam, AK Singh, S Dharmaraj… - Theranostics, 2022 - ncbi.nlm.nih.gov
Breast cancer is the most common female malignancy in both the developed and
developing world. Doxorubicin is one of the most commonly used chemotherapies for breast …

Methodological shortcomings of preclinical research on chemotherapy-induced cognitive impairment

VA Ossorio-Salazar, R D'Hooge - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
In Europe, an estimated 4 million new cancer cases were diagnosed in 2020 (ECIS-
European Cancer Information System, 2023). Patients' chances of survival improved …

Chemobrain: A review on mechanistic insight, targets and treatments

V Rao, R Bhushan, P Kumari, SP Cheruku… - Advances in cancer …, 2022 - Elsevier
Chemo-brain refers to the thinking and memory problems that occur in cancer patients
during and after chemotherapy. It is also known as cognitive dysfunction or chemo-fog. Risk …

Dopaminergic signaling as a plausible modulator of astrocytic toll-like receptor 4: a crosstalk between neuroinflammation and cognition

PC Gurram, S Manandhar, S Satarker… - CNS & Neurological …, 2023 - ingentaconnect.com
Neuroinflammation is one of the major pathological factors leading to Alzheimer's disease
(AD). The role of microglial cells in neuroinflammation associated with AD has been known …

Review of the fluoropyrimidine antidote uridine triacetate

JT Thompson, DM Wood… - British Journal of Clinical …, 2024 - Wiley Online Library
Abstract In 2015, the United States Food and Drug Administration (FDA) approved uridine
triacetate to treat overdose and severe toxicity of the fluoropyrimidine chemotherapy agents …

Chemotherapy-induced cognitive impairment: focus on the intersection of oxidative stress and TNFα

NG Rummel, L Chaiswing, S Bondada… - Cellular and Molecular …, 2021 - Springer
Chemotherapy-induced cognitive impairment (CICI) has been observed in a large fraction of
cancer survivors. Although many of the chemotherapeutic drugs do not cross the blood …