Animal models of chemotherapy-induced cognitive decline in preclinical drug development
Rationale Chemotherapy-induced cognitive impairment (CICI), chemobrain, and chemofog
are the common terms for mental dysfunction in a cancer patient/survivor under the influence …
are the common terms for mental dysfunction in a cancer patient/survivor under the influence …
Pathogenesis, assessments, and management of chemotherapy‐related cognitive impairment (CRCI): an updated literature review
L Lv, S Mao, H Dong, P Hu, R Dong - Journal of oncology, 2020 - Wiley Online Library
There are various cancer treatments at present, and chemotherapy is one of the main
methods. Chemotherapy‐related cognitive impairment (CRCI), as one of the side effects of …
methods. Chemotherapy‐related cognitive impairment (CRCI), as one of the side effects of …
Role of inflammation and oxidative stress in chemotherapy-induced neurotoxicity
Chemotherapeutic agents may adversely affect the nervous system, including the neural
precursor cells as well as the white matter. Although the mechanisms are not completely …
precursor cells as well as the white matter. Although the mechanisms are not completely …
CAR t-cell therapy in BOlogNa–NEUrotoxicity TReatment and Assessment in Lymphoma (CARBON–NEUTRAL): proposed protocol and results from an Italian study
U Pensato, G Amore, L Muccioli, S Sammali… - Journal of …, 2023 - Springer
Objective To investigate neurotoxicity clinical and instrumental features, incidence, risk
factors, and early and long-term prognosis in lymphoma patients who received CAR T-cell …
factors, and early and long-term prognosis in lymphoma patients who received CAR T-cell …
[HTML][HTML] HDAC6 inhibition reverses long-term doxorubicin-induced cognitive dysfunction by restoring microglia homeostasis and synaptic integrity
BR McAlpin, R Mahalingam, AK Singh, S Dharmaraj… - Theranostics, 2022 - ncbi.nlm.nih.gov
Breast cancer is the most common female malignancy in both the developed and
developing world. Doxorubicin is one of the most commonly used chemotherapies for breast …
developing world. Doxorubicin is one of the most commonly used chemotherapies for breast …
Methodological shortcomings of preclinical research on chemotherapy-induced cognitive impairment
VA Ossorio-Salazar, R D'Hooge - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
In Europe, an estimated 4 million new cancer cases were diagnosed in 2020 (ECIS-
European Cancer Information System, 2023). Patients' chances of survival improved …
European Cancer Information System, 2023). Patients' chances of survival improved …
Chemobrain: A review on mechanistic insight, targets and treatments
Chemo-brain refers to the thinking and memory problems that occur in cancer patients
during and after chemotherapy. It is also known as cognitive dysfunction or chemo-fog. Risk …
during and after chemotherapy. It is also known as cognitive dysfunction or chemo-fog. Risk …
Dopaminergic signaling as a plausible modulator of astrocytic toll-like receptor 4: a crosstalk between neuroinflammation and cognition
Neuroinflammation is one of the major pathological factors leading to Alzheimer's disease
(AD). The role of microglial cells in neuroinflammation associated with AD has been known …
(AD). The role of microglial cells in neuroinflammation associated with AD has been known …
Review of the fluoropyrimidine antidote uridine triacetate
JT Thompson, DM Wood… - British Journal of Clinical …, 2024 - Wiley Online Library
Abstract In 2015, the United States Food and Drug Administration (FDA) approved uridine
triacetate to treat overdose and severe toxicity of the fluoropyrimidine chemotherapy agents …
triacetate to treat overdose and severe toxicity of the fluoropyrimidine chemotherapy agents …
Chemotherapy-induced cognitive impairment: focus on the intersection of oxidative stress and TNFα
NG Rummel, L Chaiswing, S Bondada… - Cellular and Molecular …, 2021 - Springer
Chemotherapy-induced cognitive impairment (CICI) has been observed in a large fraction of
cancer survivors. Although many of the chemotherapeutic drugs do not cross the blood …
cancer survivors. Although many of the chemotherapeutic drugs do not cross the blood …