Microbiome and human health: current understanding, engineering, and enabling technologies
The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …
Engineering living therapeutics with synthetic biology
A Cubillos-Ruiz, T Guo, A Sokolovska… - Nature Reviews Drug …, 2021 - nature.com
The steadfast advance of the synthetic biology field has enabled scientists to use genetically
engineered cells, instead of small molecules or biologics, as the basis for the development …
engineered cells, instead of small molecules or biologics, as the basis for the development …
[HTML][HTML] RNA-mediated feedback control of transcriptional condensates
Regulation of biological processes typically incorporates mechanisms that initiate and
terminate the process and, where understood, these mechanisms often involve feedback …
terminate the process and, where understood, these mechanisms often involve feedback …
Materials design by synthetic biology
Synthetic biology applies genetic tools to engineer living cells and organisms analogous to
the programming of machines. In materials synthetic biology, engineering principles from …
the programming of machines. In materials synthetic biology, engineering principles from …
Dissipative DNA nanotechnology
DNA nanotechnology has emerged as a powerful tool to precisely design and control
molecular circuits, machines and nanostructures. A major goal in this field is to build devices …
molecular circuits, machines and nanostructures. A major goal in this field is to build devices …
Engineered living hydrogels
Living biological systems, ranging from single cells to whole organisms, can sense, process
information, and actuate in response to changing environmental conditions. Inspired by …
information, and actuate in response to changing environmental conditions. Inspired by …
[HTML][HTML] Next-generation machine learning for biological networks
Machine learning, a collection of data-analytical techniques aimed at building predictive
models from multi-dimensional datasets, is becoming integral to modern biological research …
models from multi-dimensional datasets, is becoming integral to modern biological research …
Tumour-targeting bacteria engineered to fight cancer
S Zhou, C Gravekamp, D Bermudes, K Liu - Nature Reviews Cancer, 2018 - nature.com
Recent advances in targeted therapy and immunotherapy have once again raised the hope
that a cure might be within reach for many cancer types. Yet, most late-stage cancers are …
that a cure might be within reach for many cancer types. Yet, most late-stage cancers are …
Programmable bacteria induce durable tumor regression and systemic antitumor immunity
S Chowdhury, S Castro, C Coker, TE Hinchliffe… - Nature medicine, 2019 - nature.com
Synthetic biology is driving a new era of medicine through the genetic programming of living
cells,. This transformative approach allows for the creation of engineered systems that …
cells,. This transformative approach allows for the creation of engineered systems that …
[HTML][HTML] Game changers in science and technology-now and beyond
UAK Betz, L Arora, RA Assal, H Azevedo… - … Forecasting and Social …, 2023 - Elsevier
The recent devastating pandemic has drastically reminded humanity of the importance of
constant scientific and technological progress. A strong interdisciplinary dialogue between …
constant scientific and technological progress. A strong interdisciplinary dialogue between …