Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …

This article introduces the physics of information in the context of molecular biology and
genomics. Entropy and information, the two central concepts of Shannon's theory of …

In evaluating current combination drug regimens for treatment of human immunodeficiency
virus (HIV) disease, it is important to determine the existence of viral reservoirs. After …

Objective: It is thought as a consequence of continuous replication, HIV-1 has acquired an
optimal fitness state and that suboptimal antiretroviral therapy selects for drug resistant …

One of the hallmarks of HIV infection is the rapid development of a genetically complex
population (quasispecies) from an initially limited number of infectious particles. Genetic …

Many RNA viruses have genetically diverse populations known as quasispecies. Important
biological characteristics may be related to the levels of diversity in the quasispecies …

The relative replicative fitness of human immunodeficiency virus type 1 (HIV-1) mutants
selected by different protease inhibitors (PIs) in vivo was determined. Each mutant was …

Two different responses to the therapy were observed in a group of patients receiving the
protease inhibitor indinavir. In one, suppression of virus replication occurred and has …

Using a previously undescribed approach, we develop an analytic model that predicts
whether an asexual population accumulates advantageous or deleterious mutations over …

We have studied the phenotypic impact of adaptative Gag cleavage site mutations in patient-
derived human immunodeficiency virus type 1 (HIV-1) variants having developed resistance …