Serotonin regulates many physiological processes including sleep, appetite, and mood.
Thus, serotonergic system is an important target in the treatment of psychiatric disorders …

Serotonin modulates several physiological and cognitive pathways throughout the human
body that affect emotions, memory, sleep, and thermal regulation. The complex nature of the …

Depression is the single largest contributor to global disability with a huge economic and
social burden on the world. There are a number of antidepressant drugs on the market, but …

Abstract Serotonin (5‐hydroxytryptophan [5‐HT]) is a biologically active amine expressed in
platelets, in gastrointestinal (GI) cells and, to a lesser extent, in the central nervous system …

1, 8-Naphthyridine nucleus belongs to significant nitrogen-containing heterocyclic
compounds which has garnered the interest of researchers due to its versatile biological …

Serotonin (5-HT) receptors are found throughout central and peripheral nervous systems,
mainly in brain regions involved in the neurobiology of anxiety and depression. 5-HT …

Among all nitrogen-containing heterocycles, the 1, 8-naphthyridine scaffold has recently
gained an immense amount of curiosity from numerous researchers across fields of …

Depression is one of the major disorders of the central nervous system worldwide and
causes disability and functional impairment. According to the World Health Organization …

Depression is one of the most prevalent mental diseases and a primary cause of disability
worldwide with high incidence and high recurrence. The current deterioration of the COVID …

In this work, a series of novel piperazine-2, 5-dione derivatives bearing indole analogs (2a-
2q) was designed and synthesized. The synthesized compounds were characterized by IR …