Sarcopenia: aging-related loss of muscle mass and function

L Larsson, H Degens, M Li, L Salviati… - Physiological …, 2019 - journals.physiology.org
Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

Fibronectin: molecular structure, fibrillar structure and mechanochemical signaling

CJ Dalton, CA Lemmon - Cells, 2021 - mdpi.com
The extracellular matrix (ECM) plays a key role as both structural scaffold and regulator of
cell signal transduction in tissues. In times of ECM assembly and turnover, cells upregulate …

Programmably controllable delivery of metastable ferrous ions for multiscale dynamic imaging guided photothermal primed chemodynamic therapy

X Zhang, S Lin, F Zhao, J Zhang, S Lei, F Bai… - Advanced …, 2023 - Wiley Online Library
Metallomodulation cell death strategies are extensively investigated for antitumor therapy,
such as cuproptosis, ferroptosis, and chemodynamic therapy (CDT). Undoubtedly, the …

Mavacamten, a precision medicine for hypertrophic cardiomyopathy: From a motor protein to patients

S Nag, SK Gollapudi, CL Del Rio, JA Spudich… - Science …, 2023 - science.org
Hypertrophic cardiomyopathy (HCM) is a primary myocardial disorder characterized by left
ventricular hypertrophy, hyperdynamic contraction, and impaired relaxation of the heart …

Active matter at the interface between materials science and cell biology

D Needleman, Z Dogic - Nature reviews materials, 2017 - nature.com
The remarkable processes that characterize living organisms, such as motility, self-healing
and reproduction, are fuelled by a continuous injection of energy at the microscale. The field …

Hydrodynamics of soft active matter

MC Marchetti, JF Joanny, S Ramaswamy… - Reviews of modern …, 2013 - APS
This review summarizes theoretical progress in the field of active matter, placing it in the
context of recent experiments. This approach offers a unified framework for the mechanical …

Direct observation of kinesin stepping by optical trapping interferometry

K Svoboda, CF Schmidt, BJ Schnapp, SM Block - Nature, 1993 - nature.com
Do biological motors move with regular steps? To address this question, we constructed
instrumentation with the spatial and temporal sensitivity to resolve movement on a molecular …

Single myosin molecule mechanics: piconewton forces and nanometre steps

JT Finer, RM Simmons, JA Spudich - Nature, 1994 - nature.com
A new in vitro assay using a feedback enhanced laser trap system allows direct
measurement of force and displacement that results from the interaction of a single myosin …

Synthetic molecular motors and mechanical machines

ER Kay, DA Leigh, F Zerbetto - … Chemie International Edition, 2007 - Wiley Online Library
The widespread use of controlled molecular‐level motion in key natural processes suggests
that great rewards could come from bridging the gap between the present generation of …

Modeling molecular motors

F Jülicher, A Ajdari, J Prost - Reviews of Modern Physics, 1997 - APS
The authors present general considerations and simple models for the operation of
isothermal motors at small scales, in asymmetric environments. Their work is inspired by …