Atherosclerosis is a chronic inflammatory disease that may ultimately lead to local
proteolysis, plaque rupture, and thrombotic vascular disease, resulting in myocardial …

The atherosclerotic vascular disease is a cardiovascular continuum in which the main role is
attributed to atherosclerosis, from its appearance to its associated complications. The …

Objective: Previous studies have shown that deficiency of M-CSF (macrophage colony-
stimulating factor; or CSF1 [colony stimulating factor 1]) dramatically reduces atherosclerosis …

The maturation and functional competence of natural killer (NK) cells is a tightly controlled
process that relies on transcription factors (TFs). Here, we identify transcriptional repressor …

Sepsis is a life-threatening condition with limited therapeutic options, characterized as
excessive systemic inflammation and multiple organ failure. Macrophages play critical roles …

Viral illnesses like SARS-CoV-2 have pathologic effects on nonrespiratory organs in the
absence of direct viral infection. We injected mice with cocktails of rodent equivalents of …

Atherosclerosis constitutes the pathological basis of life-threatening events, including heart
attack and stroke. Midkine is a heparin-binding growth factor and forms a small protein …

Mouse models have been used extensively to study human coronary artery disease (CAD)
or atherosclerosis and to test therapeutic targets. However, whether mouse and human …

Macrophages are usually educated to tumor-associated macrophages (TAMs) in cancer with
pro-tumor functions by tumor microenvironment (TME) and TAM reprogramming has been …

Aseptic loosening (AL) is the most common complication of total joint arthroplasty (TJA).
Both local inflammatory response and subsequent osteolysis around the prosthesis are the …