Quality and quantity control of gene expression by nonsense-mediated mRNA decay
T Kurosaki, MW Popp, LE Maquat - Nature reviews Molecular cell …, 2019 - nature.com
Nonsense-mediated mRNA decay (NMD) is one of the best characterized and most
evolutionarily conserved cellular quality control mechanisms. Although NMD was first found …
evolutionarily conserved cellular quality control mechanisms. Although NMD was first found …
The intricate balance between microRNA‐induced mRNA decay and translational repression
P Naeli, T Winter, AP Hackett, L Alboushi… - The FEBS …, 2023 - Wiley Online Library
Post‐transcriptional regulation of messenger RNAs (mRNAs)(ie, mechanisms that control
translation, stability and localization) is a critical focal point in spatiotemporal regulation of …
translation, stability and localization) is a critical focal point in spatiotemporal regulation of …
A human microprotein that interacts with the mRNA decapping complex
Proteomic detection of non-annotated microproteins indicates the translation of hundreds of
small open reading frames (smORFs) in human cells, but whether these microproteins are …
small open reading frames (smORFs) in human cells, but whether these microproteins are …
NMD: a multifaceted response to premature translational termination
S Kervestin, A Jacobson - Nature reviews Molecular cell biology, 2012 - nature.com
Although most mRNA molecules derived from protein-coding genes are destined to be
translated into functional polypeptides, some are eliminated by cellular quality control …
translated into functional polypeptides, some are eliminated by cellular quality control …
Decapping and decay of messenger RNA occur in cytoplasmic processing bodies
U Sheth, R Parker - Science, 2003 - science.org
A major pathway of eukaryotic messenger RNA (mRNA) turnover begins with deadenylation,
followed by decapping and 5′ to 3′ exonucleolytic decay. We provide evidence that …
followed by decapping and 5′ to 3′ exonucleolytic decay. We provide evidence that …
Nonsense-mediated mRNA decay: degradation of defective transcripts is only part of the story
F He, A Jacobson - Annual review of genetics, 2015 - annualreviews.org
Nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance mechanism that
monitors cytoplasmic mRNA translation and targets mRNAs undergoing premature …
monitors cytoplasmic mRNA translation and targets mRNAs undergoing premature …
P bodies and the control of mRNA translation and degradation
R Parker, U Sheth - Molecular cell, 2007 - cell.com
Recent results indicate that many untranslating mRNAs in somatic eukaryotic cells assemble
into related mRNPs that accumulate in specific cytoplasmic foci referred to as P bodies …
into related mRNPs that accumulate in specific cytoplasmic foci referred to as P bodies …
[HTML][HTML] Cytoplasmic RNA decay pathways-Enzymes and mechanisms
A Łabno, R Tomecki, A Dziembowski - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work
conducted over the last decades has defined the major mRNA decay pathways, as well as …
conducted over the last decades has defined the major mRNA decay pathways, as well as …
Translation drives mRNA quality control
CJ Shoemaker, R Green - Nature structural & molecular biology, 2012 - nature.com
There are three predominant forms of co-translational mRNA surveillance: nonsense-
mediated decay (NMD), no-go decay (NGD) and nonstop decay (NSD). Although discussion …
mediated decay (NMD), no-go decay (NGD) and nonstop decay (NSD). Although discussion …
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies
Small RNAs, including small interfering RNAs (siRNAs) and microRNAs (miRNAs) can
silence target genes through several different effector mechanisms. Whereas siRNA …
silence target genes through several different effector mechanisms. Whereas siRNA …