Karyotype complexity has major prognostic value in many malignancies. There is no
consensus on the definition of a complex karyotype, and the prognostic impact of karyotype …

Abstract Optical Genome Mapping (OGM) is rapidly emerging as an exciting cytogenomic
technology both for research and clinical purposes. In the last 2 years alone, multiple studies …

Complex karyotypes have been associated with inferior outcomes in chronic lymphocytic
leukemia (CLL) treated with chemoimmunotherapy (CIT), whereas their prognostic impact in …

Complex karyotype (CK) at chronic lymphocytic leukemia (CLL) diagnosis is a negative
biomarker of adverse outcome. Since the impact of CK and its subtypes, namely type-2 CK …

Mounting evidence underscores the clinical value of cytogenetic analysis in chronic
lymphocytic leukemia (CLL), particularly as it allows the identification of complex karyotype …

Chromoanagenesis constitutes a group of events that arise from single cellular events
during early development. This particular class of complex rearrangements is a newfound …

Simple Summary Genome complexity, detected by chromosome banding analysis or
chromosomal microarray analysis, is a poor prognostic factor for chronic lymphocytic …

Chromosomal abnormalities are frequent in chronic lymphocytic leukemia (CLL), and most
have prognostic value. In addition to the four well-known abnormalities (13q, 11q and 17p …

Abstract The International Clinical Advisory Committee reviewed advances in our
understanding of the clinicopathologic and biologic features of chronic lymphocytic …

Genomic characterization is an essential part of the clinical management of hematological
malignancies for diagnostic, prognostic and therapeutic purposes. Although CBA and FISH …