Over the last 50 yr, the study of intestinal peptide transport has rapidly evolved into a field
with exciting nutritional and biomedical applications. In this review, we describe from a …

1. The peptide transporters belong to the peptide transporter (PTR) family and serve as
integral membrane proteins for the cellular uptake of di-and tripeptides in the organism. By …

OBJECTIVE: Leptin was discovered in 1994 as a hormone produced by adipose tissue with
a modulatory effect on feeding behavior and weight control. Recently, the stomach has been …

Hyperoxaluria is a major risk factor for kidney stones and has no specific therapy, although
Oxalobacter formigenes colonization is associated with reduced stone risk. O. formigenes …

Intestinal inflammation is characterized by epithelial disruption, leading to loss of barrier
function and the recruitment of immune cells, including neutrophils. Although the …

The intestinal epithelium of adult humans acts as a differentially permeable barrier that
separates the potentially harmful contents of the lumen from the underlying tissues. Any …

The increase in obesity rate is a major public health issue associated with increased
pathological conditions such as type 2 diabetes or cardiovascular diseases. Obesity also …

Background PepT1, an intestinal epithelial apical di/tripeptide transporter, is normally
expressed in the small intestine and induced in colon during chronic inflammation. This …

The epithelium of the gastrointestinal tract is one of the most versatile tissues in the
organism, responsible for providing a tight barrier between dietary and bacterial antigens …

Leptin acts on its receptor (ObR) in the hypothalamus to inhibit food intake and energy
expenditure. Leptin and ObR are also expressed in the gastrointestinal tract; however, the …