Perspective: Vitamin D deficiency and COVID‐19 severity–plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis
Background SARS‐CoV‐2 coronavirus infection ranges from asymptomatic through to fatal
COVID‐19 characterized by a 'cytokine storm'and lung failure. Vitamin D deficiency has …
COVID‐19 characterized by a 'cytokine storm'and lung failure. Vitamin D deficiency has …
[HTML][HTML] Rationale and plan for vitamin D food fortification: a review and guidance paper
S Pilz, W März, KD Cashman, ME Kiely… - Frontiers in …, 2018 - frontiersin.org
Vitamin D deficiency can lead to musculoskeletal diseases such as rickets and
osteomalacia, but vitamin D supplementation may also prevent extraskeletal diseases such …
osteomalacia, but vitamin D supplementation may also prevent extraskeletal diseases such …
Interpreting type 1 diabetes risk with genetics and single-cell epigenomics
Genetic risk variants that have been identified in genome-wide association studies of
complex diseases are primarily non-coding. Translating these risk variants into mechanistic …
complex diseases are primarily non-coding. Translating these risk variants into mechanistic …
Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk
A Zhou, JB Selvanayagam… - European heart …, 2022 - academic.oup.com
Aims Low vitamin D status is associated with a higher risk for cardiovascular diseases
(CVDs). Although most existing linear Mendelian randomization (MR) studies reported a null …
(CVDs). Although most existing linear Mendelian randomization (MR) studies reported a null …
Vitamin D deficiency increases mortality risk in the UK Biobank: a nonlinear Mendelian randomization study
JP Sutherland, A Zhou, E Hyppönen - Annals of internal medicine, 2022 - acpjournals.org
Background: Low vitamin D status is associated with increased mortality, but randomized
trials on severely deficient participants are lacking. Objective: To assess genetic evidence …
trials on severely deficient participants are lacking. Objective: To assess genetic evidence …
Genetics of 35 blood and urine biomarkers in the UK Biobank
Clinical laboratory tests are a critical component of the continuum of care. We evaluate the
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …
[HTML][HTML] Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration
Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a
genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 …
genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 …
[HTML][HTML] Vitamin D testing and treatment: a narrative review of current evidence
S Pilz, A Zittermann, C Trummer… - Endocrine …, 2019 - ec.bioscientifica.com
Vitamin D testing and treatment is a subject of controversial scientific discussions, and it is
challenging to navigate through the expanding vitamin D literature with heterogeneous and …
challenging to navigate through the expanding vitamin D literature with heterogeneous and …
Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study
A Zhou, E Hyppönen - International Journal of Epidemiology, 2023 - academic.oup.com
Background Low vitamin D status is often associated with systemic low-grade inflammation
as reflected by elevated C-reactive protein (CRP) levels. We investigated the causality and …
as reflected by elevated C-reactive protein (CRP) levels. We investigated the causality and …
[HTML][HTML] Genome-wide association study for vitamin D levels reveals 69 independent loci
We aimed to increase our understanding of the genetic determinants of vitamin D levels by
undertaking a large-scale genome-wide association study (GWAS) of serum 25 …
undertaking a large-scale genome-wide association study (GWAS) of serum 25 …