With the constant threat of emergence of a novel influenza virus pandemic, there must be
continued evaluation of the molecular mechanisms that contribute to virulence. Although the …

Influenza affects approximately 1 billion individuals each year resulting in between 290,000
and 650,000 deaths. Young children and immunocompromised individuals are at a …

Please cite this paper as: McKimm‐Breschkin (2012) Influenza neuraminidase inhibitors:
Antiviral action and mechanisms of resistance. Influenza and Other Respiratory Viruses 7 …

Rapidly evolving influenza A viruses (IAVs) and influenza B viruses (IBVs) are major causes
of recurrent lower respiratory tract infections. Current influenza vaccines elicit antibodies …

In consequence of their biological effects, conformationally constrained carbocyclic β-amino
acids have generated great interest among synthetic and medicinal chemists in the past 2 …

Influenza antiviral agents play important roles in modulating disease severity and in
controlling pandemics while vaccines are prepared, but the development of resistance to …

Abstract Four World Health Organization (WHO) Collaborating Centres for Reference and
Research on Influenza and one WHO Collaborating Centre for the Surveillance …

Covering: 2000 to 2011 The imminent threat of influenza pandemics and repeatedly
reported emergence of new drug-resistant influenza virus strains demonstrate the urgent …

Many aspects of the biology and epidemiology of influenza B viruses are far less studied
than for influenza A viruses, and one of these aspects is efficacy and resistance to the …

Hemagglutinin and neuraminidase, which constitute the glycoprotein spikes expressed on
the surface of influenza A and B viruses, are the most exposed parts of the virus and play …