The goal of this critical review is to comprehensively assess the evidence for the molecular,
physiologic, and phenotypic skeletal muscle responses to resistance exercise (RE) …

Studies both in vivo and in vitro have shown that leucine at a very high dose can stimulate
muscle protein synthesis, an effect that is enhanced in vivo by insulin secreted in response …

Circadian clocks are fundamental physiological regulators of energy homeostasis, but direct
transcriptional targets of the muscle clock machinery are unknown. To understand how the …

Background Flavaglines are a family of natural products from the genus Aglaia that exhibit
anti-cancer activity in vitro and in vivo and inhibit translation initiation. They have been …

Protein synthesis requires both amino acids, as precursors, and a substantial amount of
metabolic energy. It is well established that starvation or lack of nutrients impairs protein …

This study examined the impact of leucine (Leu) derived from complete meals on stimulation
of skeletal muscle protein synthesis (MPS). Expt. 1 examined time course changes in …

Aging is associated with a progressive loss of muscle mass (sarcopenia), which increases
the risks of injury and disability. Although the mechanisms of sarcopenia are not clearly …

Leucine is a well-known activator of the mammalian target of rapamycin (mTOR). Because
mTOR signaling regulates several aspects of metabolism, the potential of leucine as a …

Branched‐chain amino acids (BCAAs), leucine, isoleucine and valine have an enormous
functional significance because of their involvement in fish physiology. Branched‐chain …

To examine which branched-chain amino acids affect the plasma glucose levels, we
investigated the effects of leucine, isoleucine, and valine (0.3 g/kg body weight po) in normal …