The aim of this work was to identify common HLA Class II alleles contributing to primary
Sjögren's syndrome (pSS) susceptibility worldwide and to analyze their biological …

Background: T lymphocyte achieves an immune response by recognizing antigen peptides
(also known as T cell epitopes) through major histocompatibility complex (MHC) molecules …

Background Identification of antigenic peptide epitopes is an essential prerequisite in T cell-
based molecular vaccine design. Computational (sequence-based and structure-based) …

Background. The interplay between female fertility and autoimmune diseases (AIDs) can
involve HLA haplotypes and micronutrients. We analyzed the distribution of HLA-DQ2/-DQ8 …

A set of new amino acid descriptors, namely factor analysis scales of generalized amino
acid information (FASGAI) involving hydrophobicity, alpha and turn propensities, bulky …

US8378072B2 - Methods for designing and synthesizing directed sequence polymer
compositions via the directed expansion of epitope permeability - Google Patents US8378072B2 …

Abstract Proteins of the Major Histocompatibility Complex (MHC) bind self and nonself
peptide antigens or epitopes within the cell and present them at the cell surface for …

Recent years have witnessed an explosive growth in available biological data pertaining to
autoimmunity research. This includes a tremendous quantity of sequence data (biological …

Thyroglobulin (Tg), a homodimer of 660 kD comprising 2748 amino acids, is the largest
autoantigen known. The prevalence of autoimmune thyroid disease, including Hashimoto's …

De novo protein design aims at determining specific amino acid sequences that will fold into
a given three-dimensional (3D) template. This is also known as the “inverse folding …