Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …

Co-inhibitory receptors, such as CTLA-4 and PD-1, have an important role in regulating T
cell responses and have proven to be effective targets in the setting of chronic diseases …

Activation of the NLRP3 inflammasome induces maturation of IL-1β and IL-18, both
validated targets for treating acute and chronic inflammatory diseases. Here, we …

The immune system has evolved to protect the host from a universe of pathogenic microbes
that are themselves constantly evolving. The immune system also helps the host eliminate …

Adipose tissue is a highly heterogeneous endocrine organ. The heterogeneity among
different anatomical depots stems from their intrinsic differences in cellular and physiological …

Engagement of antigen-specific T cell receptors (TCRs) is a prerequisite for T cell activation.
Acquisition of appropriate effector T cell function requires the participation of multiple signals …

Gut intraepithelial lymphocytes (IELs) are thought to calibrate glucagon-like peptide 1 (GLP-
1) bioavailability, thereby regulating systemic glucose and lipid metabolism. Here, we show …

Natural killer (NK) cells, the effectors of the innate immune system, have a remarkable
influence on cancer prognosis and immunotherapy. In this study, a total of 1,816 samples …

Rosacea is a common chronic inflammatory skin disease of unknown etiology. Our
knowledge about an involvement of the adaptive immune system is very limited. We …

The Src, Syk, and Tec family kinases are three of the most well characterized tyrosine kinase
families found in the human genome. Members of these kinase families function …