Regulation of visceral and epicardial adipose tissue for preventing cardiovascular injuries associated to obesity and diabetes

N González, Z Moreno-Villegas… - Cardiovascular …, 2017 - Springer
Nowadays, obesity is seriously increasing in most of the populations all over the world, and
is associated with the development and progression of high-mortality diseases such as type …

PPARs-orchestrated metabolic homeostasis in the adipose tissue

C Sun, S Mao, S Chen, W Zhang, C Liu - International journal of …, 2021 - mdpi.com
It has been more than three decades since peroxisome proliferator-activated receptors
(PPARs) were first discovered. Many investigations have revealed the central regulators of …

Global analysis of plasma lipids identifies liver-derived acylcarnitines as a fuel source for brown fat thermogenesis

J Simcox, G Geoghegan, JA Maschek, CL Bensard… - Cell metabolism, 2017 - cell.com
Cold-induced thermogenesis is an energy-demanding process that protects endotherms
against a reduction in ambient temperature. Using non-targeted liquid chromatography …

In vivo measurement of energy substrate contribution to cold‐induced brown adipose tissue thermogenesis

SM Labbé, A Caron, I Bakan, M Laplante… - The FASEB …, 2015 - Wiley Online Library
The present study was designed to investigate the effects of cold on brown adipose tissue
(BAT) energy substrate utilization in vivo using the positron emission tomography tracers …

Mapping metabolic changes by noninvasive, multiparametric, high-resolution imaging using endogenous contrast

Z Liu, D Pouli, CA Alonzo, A Varone, S Karaliota… - Science …, 2018 - science.org
Monitoring subcellular functional and structural changes associated with metabolism is
essential for understanding healthy tissue development and the progression of numerous …

Role of brown fat in lipoprotein metabolism and atherosclerosis

G Hoeke, S Kooijman, MR Boon, PCN Rensen… - Circulation …, 2016 - Am Heart Assoc
Atherosclerosis, for which hyperlipidemia is a major risk factor, is the leading cause of
morbidity and mortality in Western society, and new therapeutic strategies are highly …

Brown adipose tissue takes up plasma triglycerides mostly after lipolysis

PPSJ Khedoe, G Hoeke, S Kooijman, W Dijk… - Journal of lipid …, 2015 - ASBMB
Brown adipose tissue (BAT) produces heat by burning TGs that are stored within
intracellular lipid droplets and need to be replenished by the uptake of TG-derived FA from …

Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men

DP Blondin, HC Tingelstad, C Noll, F Frisch… - Nature …, 2017 - nature.com
In rodents, brown adipose tissue (BAT) plays an important role in producing heat to defend
against the cold and can metabolize large amounts of dietary fatty acids (DFA). The role of …

Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice

JJ Geerling, MR Boon, GC van der Zon… - Diabetes, 2014 - Am Diabetes Assoc
Metformin is the first-line drug for the treatment of type 2 diabetes. Besides its well-
characterized antihyperglycemic properties, metformin also lowers plasma VLDL triglyceride …

Fatty acid metabolism and the basis of brown adipose tissue function

M Calderon-Dominguez, JF Mir, R Fucho, M Weber… - Adipocyte, 2016 - Taylor & Francis
Obesity has reached epidemic proportions, leading to severe associated pathologies such
as insulin resistance, cardiovascular disease, cancer and type 2 diabetes. Adipose tissue …