Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes

D Milardi, E Gazit, SE Radford, Y Xu… - Chemical …, 2021 - ACS Publications
The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …

Linking lipids to Alzheimer's disease: cholesterol and beyond

G Di Paolo, TW Kim - Nature Reviews Neuroscience, 2011 - nature.com
Lipid-mediated signalling regulates a plethora of physiological processes, including crucial
aspects of brain function. In addition, dysregulation of lipid pathways has been implicated in …

Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection

J Fantini, C Di Scala, H Chahinian, N Yahi - International journal of …, 2020 - Elsevier
The recent emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is
responsible for a worldwide pandemic. Given the global health emergency, drug …

The structural basis of accelerated host cell entry by SARS‐CoV‐2

M Seyran, K Takayama, VN Uversky… - The FEBS …, 2021 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of
the pandemic coronavirus disease 2019 (COVID‐19) that exhibits an overwhelming …

Molecular activities, biosynthesis and evolution of triterpenoid saponins

JM Augustin, V Kuzina, SB Andersen, S Bak - Phytochemistry, 2011 - Elsevier
Saponins are bioactive compounds generally considered to be produced by plants to
counteract pathogens and herbivores. Besides their role in plant defense, saponins are of …

How cholesterol interacts with membrane proteins: an exploration of cholesterol-binding sites including CRAC, CARC, and tilted domains

J Fantini, FJ Barrantes - Frontiers in physiology, 2013 - frontiersin.org
The plasma membrane of eukaryotic cells contains several types of lipids displaying high
biochemical variability in both their apolar moiety (eg, the acyl chain of glycerolipids) and …

The role of cell surface sialic acids for SARS-CoV-2 infection

XL Sun - Glycobiology, 2021 - academic.oup.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a new virus that has
higher contagious capacity than any other previous human coronaviruses (HCoVs) and …

Subcellular targeting strategies for drug design and delivery

L Rajendran, HJ Knölker, K Simons - Nature reviews Drug discovery, 2010 - nature.com
Many drug targets are localized to particular subcellular compartments, yet current drug
design strategies are focused on bioavailability and tissue targeting and rarely address drug …

Synergistic antiviral effect of hydroxychloroquine and azithromycin in combination against SARS-CoV-2: What molecular dynamics studies of virus-host interactions …

J Fantini, H Chahinian, N Yahi - International journal of antimicrobial agents, 2020 - Elsevier
The emergence of SARS-coronavirus-2 (SARS-CoV-2) has led to a global pandemic
disease referred to as coronavirus disease 19 (COVID-19). Hydroxychloroquine (CLQ …

From biological membranes to biomimetic model membranes

M Eeman, M Deleu - Biotechnologie, Agronomie, Société et …, 2010 - orbi.uliege.be
Biological membranes play an essential role in the cellular protection as well as in the
control and the transport of nutrients. Many mechanisms such as molecular recognition …