Arsenic is a trace element found in the earth, s crust at an average concentration of∼ 5 μg/g
(ppm). Although its relative abundance in the earth, s crust is about 54th, arsenic can …

The first disulfide linkage-employing drug conjugate that exploits the reversible nature of this
unique covalent bond was recently approved for human use. Increasing numbers of drug …

Watching biological molecules provides clues to their function and regulation. Some of the
most powerful methods of labeling proteins for imaging use genetically encoded fluorescent …

Highlights•PDI is an important oxidase, reductase, isomerase and molecular
chaperone.•PDI expression is up-regulated in select types of cancers.•Silencing PDI results …

Summary Immunoglobulin G4 (IgG4) antibodies have been known for some time to be
functionally monovalent. Recently, the structural basis for this monovalency has been …

Thiol proteins may potentially act as redox signaling adaptor proteins, adjusting reactive
oxygen species intermediates to specific signals and redox signals to cell homeostasis. In …

Gamma-glutamyltransferase (GGT) is a key enzyme involved in glutathione metabolism and
whose expression is often significantly increased in human malignancies. In the past years …

Arsenic had been used in treating malignancies from the 18th to mid-20th century. In the
past 3 decades, arsenic was revived and shown to be able to induce complete remission …

Rats and mice with a lower capacity to produce reactive oxygen species (ROS) because of
allelic polymorphisms in the Ncf1 gene (which encodes neutrophil cytosolic factor 1) are …

Three of the most plausible biological theories of arsenic carcinogenesis are protein
binding, oxidative stress and altered DNA methylation. This review presents the role of …