Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …

Estrogen receptor-positive (ER+) breast cancer is the most common breast cancer subtype.
Treatment of ER+ breast cancer comprises interventions that suppress estrogen production …

Adipocytes are one of the primary stromal cells in many tissues, and they are considered to
play an active role in the tumor microenvironment. Cancer-associated adipocytes (CAAs) …

Summary The cytokine interleukin-6 (IL6) and its downstream effector STAT3 constitute a
key oncogenic pathway, which has been thought to be functionally connected to estrogen …

The importance and role of the estrogen receptor (ER) pathway has been well-documented
in both breast cancer (BC) development and progression. The treatment of choice in women …

Breast cancer is the most frequently diagnosed cancer and the principal cause of mortality
by malignancy in women and represents a main problem for public health worldwide. Tumor …

Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human
physiology and pathology, serving as sensors of stimuli, master regulators of downstream …

Estrogen receptor α (ER) is the major driver of∼ 75% of breast cancers, and multiple ER
targeting drugs are routinely used clinically to treat patients with ER+ breast cancer …

Estrogens and estrogen receptors (ERs) regulate metabolism in both normal physiology and
in disease. The metabolic characteristics of intrinsic breast cancer subtypes change based …

Many inflammation-associated diseases, including cancers, increase in women after
menopause and with obesity. In contrast to anti-inflammatory actions of 17β-estradiol, we …