Adipose tissue is a complex endocrine organ with an intricate role in whole body
homeostasis. Beyond storing energy, adipose tissue is fundamental in numerous processes …

The mouse is one of the most important model organisms for understanding human genetic
function and disease. This includes characterization of the factors that influence energy …

Adipose tissue (AT) secretes several adipokines that influence insulin sensitivity and
potentially link obesity to insulin resistance. Apelin, a peptide present in different tissues, is …

Apelin is a peptide known as the ligand of the G-protein-coupled receptor APJ. Several
active apelin forms exist such as apelin-36, apelin-17, apelin-13, and the pyroglutamated …

The apelin receptor (APJ) is a member of the family A of G-protein-coupled receptors
(GPCRs) and is involved in range of physiological and pathological functions, including fluid …

A gene encoding a novel class a G-protein-coupled receptor was discovered in 1993 by
homology cloning and was called APJ. It was designated an “orphan” receptor until 1998 …

First seen as a fat-storage tissue, the adipose tissue is considered as a critical player in the
endocrine system. Precisely, adipose tissue can produce an array of bioactive factors …

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of COVID-19, is
reported to increase the rate of mortality worldwide. COVID-19 is associated with acute …

Apelin and apela (ELABELA/ELA/Toddler) are two peptide ligands for a class A G-protein-
coupled receptor named the apelin receptor (AR/APJ/APLNR). Ligand-AR interactions have …

The G protein-coupled apelin receptor (APJ) binds the endogenous peptide apelin and has
been shown to have roles in many physiological systems. Thus far, distribution studies have …