Chromosomal instability (CIN) is a hallmark of human cancer, and it is associated with poor
prognosis, metastasis, and therapeutic resistance. CIN results from errors in chromosome …

Aberrant chromosomal architecture, ranging from small insertions or deletions to large
chromosomal alterations, is one of the most common characteristics of cancer genomes …

A challenge in oncology is to rationally and effectively integrate immunotherapy with
traditional modalities, including radiotherapy. Here, we demonstrate that radiotherapy …

Chromosomal instability is a hallmark of cancer that results from ongoing errors in
chromosome segregation during mitosis. Although chromosomal instability is a major driver …

Cyclic GMP-AMP (cGAMP) is an intracellular second messenger that is synthesized in
response to cytosolic double-stranded DNA and activates the innate immune STING …

Ionizing radiation causes DNA damage and is a mainstay for cancer treatment, but
understanding of its genomic impact is limited. We analyzed mutational spectra following …

Abstract Since 1969, the European Union approves food-grade titanium dioxide (TiO2), also
known as E171 colouring food additive. E171 is a mixture of micro-sized particles (MPs) and …

Large-scale, massively parallel sequencing of human cancer samples has revealed
tremendous genetic heterogeneity within individual tumors. Indeed, tumors are composed of …

Radiation-induced chromosomal aberrations represent an early marker of late effects,
including cell killing and transformation. The measurement of cytogenetic damage in tissues …

Micronuclei (MN), the small nucleus-like bodies separated from the primary nucleus, can
exist in cells with numerical and/or structural chromosomal aberrations in apparently normal …