Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous
compounds, including lipid esters. Physiological functions of carboxylesterases in lipid …

Adult hepatocyte identity is constructed throughout embryonic development and fine-tuned
after birth. A multinodular network of transcription factors, along with pre-mRNA splicing …

Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear
receptor family whose expression and activities are restricted to a limited number of organs …

Excessive alcohol consumption leads to damage to the organs of the body. More
importantly, the liver is majorly affected organ upon alcohol consumption for most of the …

Carboxylesterase (CE) is crucial in metabolizing ester-containing biomolecules and is
particularly significant in liver metabolic diseases. Herein, we present the first activatable …

Alcoholic liver disease (ALD), a leading cause of chronic liver injury worldwide, comprises a
range of disorders including simple steatosis, steatohepatitis, cirrhosis, and hepatocellular …

Background and Aims Hepatocyte nuclear factor 4α (HNF4α) is highly enriched in the liver,
but its role in the progression of nonalcoholic liver steatosis (NAFL) to NASH has not been …

The ability to adapt to low-nutrient microenvironments is essential for tumor cell survival and
progression in solid cancers, such as colorectal carcinoma (CRC). Signaling by the NF-κB …

Hepatocyte nuclear factor 4-alpha (HNF4α) is a highly conserved member of nuclear
receptor superfamily of ligand-dependent transcription factors that is expressed in liver and …

Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver
disease worldwide. It refers to a range of liver conditions affecting people who drink little or …