[HTML][HTML] The physiological, biochemical, and molecular roles of zinc transporters in zinc homeostasis and metabolism

T Kambe, T Tsuji, A Hashimoto… - Physiological …, 2015 - journals.physiology.org
Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets

B Chen, P Yu, WN Chan, F Xie, Y Zhang… - … and Targeted Therapy, 2024 - nature.com
Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

Roles of zinc signaling in the immune system

S Hojyo, T Fukada - Journal of immunology research, 2016 - Wiley Online Library
Zinc (Zn) is an essential micronutrient for basic cell activities such as cell growth,
differentiation, and survival. Zn deficiency depresses both innate and adaptive immune …

Zinc and human health: an update

CT Chasapis, AC Loutsidou, CA Spiliopoulou… - Archives of …, 2012 - Springer
The importance of micronutrients in health and nutrition is undisputable, and among them,
zinc is an essential element whose significance to health is increasingly appreciated and …

Mammalian zinc transport, trafficking, and signals

RJ Cousins, JP Liuzzi, LA Lichten - Journal of Biological Chemistry, 2006 - ASBMB
Structural, catalytic, and regulatory functions of zinc in biology continue to be defined. The
number of genes coding for proteins with zinc-binding domains is conservatively estimated …

Role of zinc in female reproduction

TB Garner, JM Hester, A Carothers… - Biology of …, 2021 - academic.oup.com
Zinc is a critical component in a number of conserved processes that regulate female germ
cell growth, fertility, and pregnancy. During follicle development, a sufficient intracellular …

Molecular and genetic features of zinc transporters in physiology and pathogenesis

T Fukada, T Kambe - Metallomics, 2011 - academic.oup.com
Zinc (Zn) is a vital element. It plays indispensable roles in multifarious cellular processes,
affecting the expression and activity of a variety of molecules, including transcription factors …

Intracellular zinc homeostasis and zinc signaling

M Murakami, T Hirano - Cancer science, 2008 - Wiley Online Library
Zinc (Zn) is an essential heavy metal that is incorporated into a number of human Zn
metalloproteins. Zn plays important roles in nucleic acid metabolism, cell replication, and …

Functional significance of zinc-related signaling pathways in immune cells

H Haase, L Rink - Annual review of nutrition, 2009 - annualreviews.org
Recent years have brought a paradigm shift for the role of the essential trace element zinc in
immunity. Although its function as a structural component of many enzymes has been known …

Zinc transporter 1 (ZNT1) expression on the cell surface is elaborately controlled by cellular zinc levels

Y Nishito, T Kambe - Journal of Biological Chemistry, 2019 - ASBMB
Zinc transporter 1 (ZNT1) is the only zinc transporter predominantly located on the plasma
membrane, where it plays a pivotal role exporting cytosolic zinc to the extracellular space …