Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity

M Cooke, MG Kazanietz - Science Signaling, 2022 - science.org
Diacylglycerol (DAG) is a lipid second messenger that is generated in response to
extracellular stimuli and channels intracellular signals that affect mammalian cell …

Multifaceted functions of protein kinase D in pathological processes and human diseases

X Zhang, J Connelly, Y Chao, QJ Wang - Biomolecules, 2021 - mdpi.com
Protein kinase D (PKD) is a family of serine/threonine protein kinases operating in the
signaling network of the second messenger diacylglycerol. The three family members …

[HTML][HTML] Long noncoding RNA MALAT1 promotes malignant development of esophageal squamous cell carcinoma by targeting β-catenin via Ezh2

W Wang, Y Zhu, S Li, X Chen, G Jiang, Z Shen… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Evidences have shown that lncRNAs involve in the initiation and progression of various
cancers including esophageal squamous cell carcinoma (ESCC). The aberrant expression …

Protein kinase D signaling in cancer: A friend or foe?

A Roy, J Ye, F Deng, QJ Wang - … et Biophysica Acta (BBA)-Reviews on …, 2017 - Elsevier
Protein kinase D is a family of evolutionarily conserved serine/threonine kinases that
belongs to the Ca++/Calmodulin-dependent kinase superfamily. Signal transduction …

Acromegaly is associated with increased cancer risk: a survey in Italy

M Terzolo, G Reimondo, P Berchialla… - Endocrine-related …, 2017 - erc.bioscientifica.com
Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have been linked
to predisposition to pituitary adenomas. However, the mechanism by which this occurs …

Deciphering the role of protein kinase D1 (PKD1) in cellular proliferation

I Youssef, JM Ricort - Molecular Cancer Research, 2019 - AACR
Abstract Protein kinase D1 (PKD1) is a serine/threonine kinase that belongs to the
calcium/calmodulin-dependent kinase family, and is involved in multiple mechanisms …

Somatic genetic variation in solid pseudopapillary tumor of the pancreas by whole exome sequencing

M Guo, G Luo, K Jin, J Long, H Cheng, Y Lu… - International journal of …, 2017 - mdpi.com
Solid pseudopapillary tumor of the pancreas (SPT) is a rare pancreatic disease with a
unique clinical manifestation. Although CTNNB1 gene mutations had been universally …

Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer

N Durand, S Borges, P Storz - Cellular and Molecular Life Sciences, 2015 - Springer
The protein kinase D (PKD) family members, PKD1, PKD2 and PKD3 constitute a family of
serine/threonine kinases that are essential regulators of cell migration, proliferation and …

[HTML][HTML] The AR/NCOA1 axis regulates prostate cancer migration by involvement of PRKD1

B Luef, F Handle, G Kharaishvili… - Endocrine-Related …, 2016 - erc.bioscientifica.com
Due to the urgent need for new prostate cancer (PCa) therapies, the role of androgen
receptor (AR)-interacting proteins should be investigated. In this study we aimed to address …

Synthesis and Antitumor Activity of Brominated-Ormeloxifene (Br-ORM) against Cervical Cancer

M Sikander, S Malik, J Apraku, S Kumari, P Khan… - ACS …, 2023 - ACS Publications
Aberrant regulation of β-catenin signaling is strongly linked with cancer proliferation,
invasion, migration, and metastasis, thus, small molecules that can inhibit this pathway might …