The Skyline ecosystem: Informatics for quantitative mass spectrometry proteomics
Skyline is a freely available, open‐source Windows client application for accelerating
targeted proteomics experimentation, with an emphasis on the proteomics and mass …
targeted proteomics experimentation, with an emphasis on the proteomics and mass …
Addressing global ruminant agricultural challenges through understanding the rumen microbiome: past, present, and future
The rumen is a complex ecosystem composed of anaerobic bacteria, protozoa, fungi,
methanogenic archaea and phages. These microbes interact closely to breakdown plant …
methanogenic archaea and phages. These microbes interact closely to breakdown plant …
Sixteen facial expressions occur in similar contexts worldwide
Understanding the degree to which human facial expressions co-vary with specific social
contexts across cultures is central to the theory that emotions enable adaptive responses to …
contexts across cultures is central to the theory that emotions enable adaptive responses to …
A deep proteome and transcriptome abundance atlas of 29 healthy human tissues
Abstract Genome‐, transcriptome‐and proteome‐wide measurements provide insights into
how biological systems are regulated. However, fundamental aspects relating to which …
how biological systems are regulated. However, fundamental aspects relating to which …
Stress-triggered phase separation is an adaptive, evolutionarily tuned response
JA Riback, CD Katanski, JL Kear-Scott, EV Pilipenko… - Cell, 2017 - cell.com
In eukaryotic cells, diverse stresses trigger coalescence of RNA-binding proteins into stress
granules. In vitro, stress-granule-associated proteins can demix to form liquids, hydrogels …
granules. In vitro, stress-granule-associated proteins can demix to form liquids, hydrogels …
Transcriptome and translatome co-evolution in mammals
ZY Wang, E Leushkin, A Liechti, S Ovchinnikova… - Nature, 2020 - nature.com
Gene-expression programs define shared and species-specific phenotypes, but their
evolution remains largely uncharacterized beyond the transcriptome layer. Here we report …
evolution remains largely uncharacterized beyond the transcriptome layer. Here we report …
Integration of omic networks in a developmental atlas of maize
Coexpression networks and gene regulatory networks (GRNs) are emerging as important
tools for predicting functional roles of individual genes at a system-wide scale. To enable …
tools for predicting functional roles of individual genes at a system-wide scale. To enable …
Unification of protein abundance datasets yields a quantitative Saccharomyces cerevisiae proteome
Protein activity is the ultimate arbiter of function in most cellular pathways, and protein
concentration is fundamentally connected to protein action. While the proteome of yeast has …
concentration is fundamentally connected to protein action. While the proteome of yeast has …
[HTML][HTML] Improved ribosome-footprint and mRNA measurements provide insights into dynamics and regulation of yeast translation
Ribosome-footprint profiling provides genome-wide snapshots of translation, but technical
challenges can confound its analysis. Here, we use improved methods to obtain ribosome …
challenges can confound its analysis. Here, we use improved methods to obtain ribosome …
GPCRomics: an approach to discover GPCR drug targets
G protein-coupled receptors (GPCRs) are targets for∼ 35% of approved drugs but only∼
15% of the∼ 800 human GPCRs are currently such targets. GPCRomics, the use of …
15% of the∼ 800 human GPCRs are currently such targets. GPCRomics, the use of …