Integrating environment and aging research: opportunities for synergy and acceleration

KMC Malecki, JK Andersen, AM Geller… - Frontiers in aging …, 2022 - frontiersin.org
Despite significant overlaps in mission, the fields of environmental health sciences and
aging biology are just beginning to intersect. It is increasingly clear that genetics alone does …

A scoping review on the characteristics of human exposome studies

N Haddad, XD Andrianou, KC Makris - Current Pollution Reports, 2019 - Springer
Embraced as a breaking through methodological framework, the exposome is accompanied
by novel exposure assessment methods and data processing tools or models. However …

The health opportunity index: Understanding the input to disparate health outcomes in vulnerable and high-risk census tracts

CN Ogojiaku, JC Allen, R Anson-Dwamena… - International journal of …, 2020 - mdpi.com
The Health Opportunity Index (HOI) is a multivariate tool that can be more efficiently used to
identify and understand the interplay of complex social determinants of health (SDH) at the …

The public health exposome and pregnancy-related mortality in the United States: a high-dimensional computational analysis

EW Harville, SK Grady, MA Langston, PJ Juarez… - BMC public health, 2022 - Springer
Background Racial inequities in maternal mortality in the US continue to be stark. Methods
The 2015–2018, 4-year total population, county-level, pregnancy-related mortality ratio …

Community-level exposomics: a population-centered approach to address public health concerns

JA Stingone, AM Geller, DB Hood, KC Makris… - …, 2023 - academic.oup.com
Environmental factors affecting health and vulnerability far outweigh genetics in accounting
for disparities in health status and longevity in US communities. The concept of the …

Particulate matter exposure across Latino ethnicities

K Ard, D Fisher-Garibay, D Bonner - International Journal of …, 2021 - mdpi.com
The Hispanic/Latino health paradox is the well-known health advantage seen across the
Hispanic/Latino racial category in the US. However, this racial category collapses several …

Questionnaire-based exposome-wide association studies for common diseases in the Personalized Environment and Genes Study

D Lloyd, JS House, FS Akhtari, CP Schmitt… - …, 2024 - academic.oup.com
The exposome collectively refers to all exposures, beginning in utero and continuing
throughout life, and comprises not only standard environmental exposures such as point …

Big Data to Knowledge Analytics Reveals the Zika Virus Epidemic as Only One of Multiple Factors Contributing to a Year-Over-Year 28-Fold Increase in Microcephaly …

MP Cifuentes, CM Suarez, R Cifuentes… - International Journal of …, 2022 - mdpi.com
During the 2015–2016 Zika Virus (ZIKV) epidemic in Brazil, the geographical distributions of
ZIKV infection and microcephaly outbreaks did not align. This raised doubts about the virus …

Inclusion of Social and Structural Determinants of Health to Advance Understanding of their Influence on the Biology of Chronic Disease

RT Emeny, K Zhang, D Goodman, A Dev… - Current …, 2022 - Wiley Online Library
Abstract Social Determinants of Health (SDOH) consider social, political, and economic
factors that contribute to health disparities in patients and populations. The most common …

Spatiotemporal strategies to identify aggressive biology in precancerous breast biopsies

DE Frankhauser, T Jovanovic‐Talisman… - WIREs mechanisms …, 2021 - Wiley Online Library
Over 90% of breast cancer is cured; yet there remain highly aggressive breast cancers that
develop rapidly and are extremely difficult to treat, much less prevent. Breast cancers that …