Pyrazoline core is a very interesting five‐membered heterocycle, which has been explored
in recent years due to its vast applications as the core structure of bioactive and industrial …

Depression is one of the key conditions addressed by the Mental Health Gap Action
Programme (mhGAP) of WHO that can lead to self-harm and suicide. Depression is …

Constructing a new antibacterial structural framework is an effective strategy to combat drug
resistance. This work discovered a class of naphthalimidopropanediols (NIOLs) as a novel …

Lead discovery and molecular target identification are important for developing novel
pesticides. Scaffold hopping, an effective approach of modern medicinal and agrochemical …

A total of 14 acyl hydrazine derivatives (ACH1–ACH14) were developed and examined for
their ability to block monoamine oxidase (MAO). Thirteen analogues showed stronger …

A new series of ethyl-(E)-4-(2-(2-arylidenehydrazinyl)-2-oxoethyl) piperazine-1-carboxylates
(hydrazones) 4a-4e and 5a-5c were designed and synthesized from 1 …

Pyrazole-based carbohydrazone hybrids have been considered to be a remarkable class of
compounds in pharmaceutical chemistry. Here, we reported bioactivities of 4-(3-(2 …

This study aimed to develop novel rapid-acting antidepressants with sustained efficacy and
favorable safety profiles. We designed and synthesized a series of fluorine-containing …

Pyrazolines are five-membered heterocyclic compounds containing two nitrogen atoms that
represent a privileged scaffold for various bioactive compounds with diverse …

Cancer is still a relentless public health issue. Particularly, colorectal cancer is the third most
prevalent cancer in men and the second in women. Moreover, cancer development and …