Enzymes play key roles in fungal pathogenesis. Manipulation of enzyme expression or
activity can significantly alter the infection process, and enzyme expression profiles can be a …

The dramatic increase in fungal diseases in recent years can be attributed to the increased
aggressiveness of medical therapy and other human activities. Immunosuppressed patients …

Cryptococcus neoformans is an opportunistic fungal pathogen that causes cryptococcal
meningoencephalitis, particularly in immunocompromised patients. The fungal cell wall is an …

We investigated here the potential role of Toll‐like receptors (TLR) and the adaptor protein
MyD88 in innate immunity responses to Cryptococcus neoformans, a pathogenic …

Chitin is an essential component of the cell wall of Cryptococcus neoformans conferring
structural rigidity and integrity under diverse environmental conditions. Chitin deacetylase …

Development of a vaccine to protect against cryptococcosis is a priority given the enormous
global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery …

ABSTRACT A vaccine capable of protecting at-risk persons against infections due to
Cryptococcus neoformans and Cryptococcus gattii could reduce the substantial global …

Cryptococcosis remains a significant cause of morbidity and mortality world-wide,
particularly among AIDS patients. Yet, to date, there are no licensed vaccines clinically …

Cryptococcus neoformans is the leading cause of fungal meningitis in humans. Production
of a polysaccharide capsule is a key virulence property for the fungus and capsule synthesis …

Cryptococcosis is a potentially lethal disease caused by fungal pathogens including
Cryptococcus neoformans and Cryptococcus gattii species complex. These fungal …