Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early-and late-phase COVID-19

J Radke, J Meinhardt, T Aschman, RL Chua… - Nature …, 2024 - nature.com
Neurological symptoms, including cognitive impairment and fatigue, can occur in both the
acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the …

[HTML][HTML] A host signature based on TRAIL, IP-10, and CRP for reducing antibiotic overuse in children by differentiating bacterial from viral infections: a prospective …

C Papan, A Argentiero, M Porwoll, U Hakim… - Clinical Microbiology …, 2022 - Elsevier
Objectives Identifying infection aetiology is essential for appropriate antibiotic use. Previous
studies have shown that a host-protein signature consisting of TNF-related apoptosis …

Future biomarkers for infection and inflammation in febrile children

J Zandstra, I Jongerius, TW Kuijpers - Frontiers in immunology, 2021 - frontiersin.org
Febrile patients, suffering from an infection, inflammatory disease or autoimmunity may
present with similar or overlapping clinical symptoms, which makes early diagnosis difficult …

[HTML][HTML] Myxovirus resistance protein A for discriminating between viral and bacterial lower respiratory tract infections in children–The TREND study

S Rhedin, A Eklundh, M Ryd-Rinder, V Peltola… - Clinical Microbiology …, 2022 - Elsevier
Objective Discriminating between viral and bacterial lower respiratory tract infection (LRTI)
in children is challenging, leading to an excessive use of antibiotics. Myxovirus resistance …

The central nervous system's proteogenomic and spatial imprint upon systemic viral infections with SARS-CoV-2

J Radke, J Meinhardt, T Aschman, RL Chua… - medRxiv, 2023 - medrxiv.org
In COVID-19 neurological alterations are noticed during the systemic viral infection. Various
pathophysiological mechanisms on the central nervous system (CNS) have been suggested …

MxA for differentiating viral and bacterial infections in adults: a prospective, exploratory study

M Metz, GA Gualdoni, HM Winkler, AM Warenits… - Infection, 2023 - Springer
Purpose Inappropriate antibiotic prescription in patients with viral infections contributes to
the surge of antibiotic resistance. Viral infections induce the expression of the antiviral …

Evaluation of a Novel Point-of-Care Blood Myxovirus Resistance Protein A Measurement for the Detection of Viral Infection at the Pediatric Emergency Department

R Piri, L Ivaska, AM Kujari, I Julkunen… - The Journal of …, 2024 - academic.oup.com
Background Prompt differentiation of viral from bacterial infections in febrile children is
pivotal in reducing antibiotic overuse. Myxovirus resistance protein A (MxA) is a promising …

Blood myxovirus resistance protein‐1 measurement in the diagnostic work‐up of suspected COVID‐19 infection in the emergency department

K Tong‐Minh, S van Hooijdonk… - Immunity …, 2022 - Wiley Online Library
Abstract Introduction Myxovirus resistance protein 1 (MxA) is a biomarker that is elevated in
patients with viral infections. The goal of this study was to evaluate the diagnostic value of …

Determination of systemic inflammation response index (SIRI), systemic inflammatory index (SII), HMGB1, Mx1 and TNF levels in neonatal calf diarrhea with systemic …

Ö Aydın, BA Yıldırım - Veterinary Immunology and Immunopathology, 2024 - Elsevier
The objective of this study was to examine the values of MX dynamin-like GTPase 1 (Mx1),
high mobility group box-1 (HMGB1), systemic inflammatory response index (SIRI), systemic …

Commentary: Serum Calprotectin Is a Valid Biomarker in Distinction of Bacterial Urinary Tract Infection From Viral Respiratory Illness in Children Under 3 Years of Age

B Adasevic, D Turudic, D Milosevic - Frontiers in Pediatrics, 2022 - frontiersin.org
This article aims to analyze the performance of various biomarkers in distinguishing urinary
tract infections (UTI) from viral respiratory illness (RI) using receiver operating characteristic …