The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
Endometriosis is a common condition associated with debilitating pelvic pain and infertility.
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …
The role of epigenetic mechanisms in the regulation of gene expression in the cyclical endometrium
AM Retis-Resendiz, IN González-García… - Clinical …, 2021 - Springer
Background The human endometrium is a highly dynamic tissue whose function is mainly
regulated by the ovarian steroid hormones estradiol and progesterone. The serum levels of …
regulated by the ovarian steroid hormones estradiol and progesterone. The serum levels of …
Genetic, epigenetic, and steroidogenic modulation mechanisms in endometriosis
A Zubrzycka, M Zubrzycki, E Perdas… - Journal of clinical …, 2020 - mdpi.com
Endometriosis is a chronic gynecological disease, affecting up to 10% of reproductive-age
women. The exact cause of the disease is unknown; however, it is a heritable condition …
women. The exact cause of the disease is unknown; however, it is a heritable condition …
[HTML][HTML] A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypes
Endometriosis is associated with increased risk of epithelial ovarian cancers (EOCs). Using
data from large endometriosis and EOC genome-wide association meta-analyses, we …
data from large endometriosis and EOC genome-wide association meta-analyses, we …
New concepts on the etiology of endometriosis
Endometriosis is a serious, chronic disorder where endometrial tissue grows outside the
uterus, causing severe pelvic pain and infertility. It affects 11% of women. Endometriosis is a …
uterus, causing severe pelvic pain and infertility. It affects 11% of women. Endometriosis is a …
Gene expression profiles separate endometriosis lesion subtypes and indicate a sensitivity of endometrioma to estrogen suppressive treatments through elevated …
S Marla, S Mortlock, T Heinosalo, M Poutanen… - BMC medicine, 2023 - Springer
Background Endometriosis is a common, gynaecological disease characterised by the
presence of endometrial-like cells growing outside the uterus. Lesions appear at multiple …
presence of endometrial-like cells growing outside the uterus. Lesions appear at multiple …
Long noncoding RNA LINC00339 promotes renal tubular epithelial pyroptosis by regulating the miR‐22‐3p/NLRP3 axis in calcium oxalate–induced kidney stone
Z Song, Y Zhang, B Gong, H Xu, Z Hao… - Journal of Cellular …, 2019 - Wiley Online Library
This study aims to investigate the role of long noncoding RNA (lncRNA) long intergenic
nonprotein coding RNA 339 (LINC00339) in regulating renal tubular epithelial pyroptosis in …
nonprotein coding RNA 339 (LINC00339) in regulating renal tubular epithelial pyroptosis in …
Whole-tissue deconvolution and scRNAseq analysis identify altered endometrial cellular compositions and functionality associated with endometriosis
DG Bunis, W Wang, J Vallvé-Juanico… - Frontiers in …, 2022 - frontiersin.org
The uterine lining (endometrium) exhibits a pro-inflammatory phenotype in women with
endometriosis, resulting in pain, infertility, and poor pregnancy outcomes. The full …
endometriosis, resulting in pain, infertility, and poor pregnancy outcomes. The full …
A molecular staging model for accurately dating the endometrial biopsy
WT Teh, J Chung, SJ Holdsworth-Carson… - Nature …, 2023 - nature.com
Natural variability in menstrual cycle length, coupled with rapid changes in endometrial
gene expression, makes it difficult to accurately define and compare different stages of the …
gene expression, makes it difficult to accurately define and compare different stages of the …
Tissue specific regulation of transcription in endometrium and association with disease
STUDY QUESTION Are genetic effects on endometrial gene expression tissue specific
and/or associated with reproductive traits and diseases? SUMMARY ANSWER Analyses of …
and/or associated with reproductive traits and diseases? SUMMARY ANSWER Analyses of …